Funzole
Generic Name
Fluconazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| funzole 50 mg capsule | ৳ 8.00 | N/A |
| funzole 150 mg capsule | ৳ 22.00 | N/A |
| funzole 50 mg suspension | ৳ 78.00 | N/A |
Description
Overview of the medicine
Funzole (Fluconazole) is an antifungal medication used to treat various fungal infections, including vaginal candidiasis, oral thrush, esophageal candidiasis, and systemic fungal infections.
Uses & Indications
Dosage
Adults
Vaginal candidiasis: 150 mg single oral dose. Oropharyngeal candidiasis: 50-200 mg once daily for 7-14 days. Systemic candidiasis: 400 mg on day 1, then 200-400 mg once daily. Cryptococcal meningitis: 400 mg on day 1, then 200-400 mg once daily for 10-12 weeks after CSF culture becomes negative.
Elderly
No dosage adjustment usually required unless there is renal impairment.
Renal_impairment
Dosage adjustment needed for creatinine clearance < 50 mL/min (e.g., 50% of recommended dose for 20-50 mL/min, 25% for < 20 mL/min).
How to Take
Oral capsules/suspension can be taken with or without food. IV infusion should be administered over 1-2 hours.
Mechanism of Action
Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is essential for the conversion of lanosterol to ergosterol. Ergosterol is a vital component of the fungal cell membrane, and its depletion leads to increased cell membrane permeability and cell death.
Pharmacokinetics
Onset
Within 24 hours for vaginal candidiasis, longer for other systemic infections.
Excretion
Mainly renal, with about 80% of the dose excreted unchanged in urine.
Half life
Approximately 30 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally (over 90%), peak plasma concentrations reached within 1-2 hours. Bioavailability is not affected by food.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin (due to risk of QT prolongation and torsades de pointes)
Drug Interactions
Warfarin
Increased prothrombin time, monitor INR.
Phenytoin
Increased plasma concentrations, monitor phenytoin levels.
Rifampicin
Decreased fluconazole levels, consider increasing fluconazole dose.
Sulfonylureas
Increased plasma concentrations, monitor glucose.
Hydrochlorothiazide
Increased fluconazole levels.
Cyclosporine, Tacrolimus
Increased plasma concentrations, monitor levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Treatment is symptomatic and supportive; gastric lavage may be considered. Hemodialysis significantly reduces plasma concentrations.
Pregnancy & Lactation
Pregnancy Category D (single dose for vaginal candidiasis is C). Should be avoided during pregnancy unless benefits outweigh risks. Small amounts excreted in breast milk; use with caution.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin (due to risk of QT prolongation and torsades de pointes)
Drug Interactions
Warfarin
Increased prothrombin time, monitor INR.
Phenytoin
Increased plasma concentrations, monitor phenytoin levels.
Rifampicin
Decreased fluconazole levels, consider increasing fluconazole dose.
Sulfonylureas
Increased plasma concentrations, monitor glucose.
Hydrochlorothiazide
Increased fluconazole levels.
Cyclosporine, Tacrolimus
Increased plasma concentrations, monitor levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Treatment is symptomatic and supportive; gastric lavage may be considered. Hemodialysis significantly reduces plasma concentrations.
Pregnancy & Lactation
Pregnancy Category D (single dose for vaginal candidiasis is C). Should be avoided during pregnancy unless benefits outweigh risks. Small amounts excreted in breast milk; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, varies by specific product and formulation
Availability
Pharmacies, Hospitals
Approval Status
FDA/DGDA approved
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for its efficacy and safety in various fungal infections.
Lab Monitoring
- Liver function tests (LFTs) (especially in patients with underlying liver disease or prolonged treatment)
- Renal function tests (especially in patients with renal impairment)
- Electrolyte levels (potassium, magnesium, calcium) if risk for QT prolongation
Doctor Notes
- Counsel patients on potential drug interactions, especially with other QT-prolonging agents.
- Monitor LFTs during prolonged therapy, especially in high-risk patients.
- Advise patients to seek immediate medical attention if signs of severe skin reactions occur.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Report any signs of liver problems (e.g., unusual fatigue, yellowing of skin/eyes, dark urine).
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or seizures in some patients; advise caution when driving or operating machinery until effects are known.
Lifestyle Advice
- Maintain good hygiene to prevent recurrence of fungal infections.
- Avoid sharing personal items that can spread fungal infections.
- Wear breathable clothing, especially for skin/nail infections.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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