Furex
Generic Name
Furex-15-gm-Injection
Manufacturer
MediPharm Innovations Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| furex 15 gm injection | ৳ 220.00 | N/A |
Description
Overview of the medicine
Furex-15-gm-Injection is a powerful nonsteroidal anti-inflammatory drug (NSAID) designed for rapid relief of acute pain and inflammation. It is administered parenterally for conditions requiring immediate analgesic and anti-inflammatory effects.
Uses & Indications
Dosage
Adults
Initially, 15 mg by slow intravenous infusion or intramuscular injection once daily. May increase to 30 mg daily in divided doses based on response and tolerability. Maximum daily dose 30 mg.
Elderly
Lower doses may be required, generally starting at 15 mg once daily. Monitor renal function closely. Adjust dose based on individual response and tolerability.
Renal_impairment
Use with caution. Dosage reduction may be necessary. For creatinine clearance <30 mL/min, use is generally not recommended or requires significant dose reduction and monitoring. Refer to specific guidelines.
How to Take
For intravenous administration, Furex-15-gm-Injection should be diluted and infused slowly over 15-30 minutes. For intramuscular administration, inject deep into a large muscle mass. Do not administer intra-arterially. Always follow healthcare professional's instructions.
Mechanism of Action
Furex primarily acts by inhibiting cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate pain, inflammation, and fever. By reducing prostaglandin production, Furex effectively reduces these symptoms.
Pharmacokinetics
Onset
Within 15-30 minutes for analgesic effects, 1-2 hours for anti-inflammatory effects.
Excretion
Excreted mainly through the urine (60-70%) and feces (30-40%) as metabolites.
Half life
Approximately 2-4 hours, with variability.
Absorption
Rapidly and completely absorbed following intramuscular or intravenous administration, reaching peak plasma concentrations within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP2C9, CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Furex or other NSAIDs (e.g., aspirin-induced asthma)
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of NSAID overdose include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rare cases of severe overdose may lead to acute renal failure, hepatic damage, respiratory depression, and coma. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if ingestion was recent. Maintain fluid and electrolyte balance. Monitor renal and hepatic function.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use in first and second trimesters only if clearly needed and potential benefits outweigh risks. Lactation: Excreted in breast milk in small amounts; use with caution. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Furex or other NSAIDs (e.g., aspirin-induced asthma)
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of NSAID overdose include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rare cases of severe overdose may lead to acute renal failure, hepatic damage, respiratory depression, and coma. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if ingestion was recent. Maintain fluid and electrolyte balance. Monitor renal and hepatic function.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use in first and second trimesters only if clearly needed and potential benefits outweigh risks. Lactation: Excreted in breast milk in small amounts; use with caution. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored under recommended conditions.
Availability
Hospitals, Clinics, Retail Pharmacies
Approval Status
Approved
Patent Status
Patent pending
Clinical Trials
Phase III clinical trials demonstrated significant efficacy in reducing acute post-operative pain and inflammation, with a favorable safety profile compared to placebo. Ongoing post-marketing surveillance.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Stool for occult blood (if GI symptoms)
- Blood pressure monitoring
Doctor Notes
- Administer with caution in patients with a history of hypertension or heart failure.
- Regular monitoring of renal function is recommended during prolonged therapy.
- Advise patients on symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Inform your doctor about all existing medical conditions and medications.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) immediately.
- Avoid self-medication with other NSAIDs while on Furex.
- Follow the prescribed dosage and administration instructions carefully.
Missed Dose Advice
Since this is an injection administered by a healthcare professional, a missed dose is unlikely. If a scheduled dose is missed, contact your doctor or nurse immediately to reschedule.
Driving Precautions
Furex may cause dizziness or drowsiness in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Limit alcohol intake, as it may increase the risk of stomach problems.
- Avoid smoking, as it may worsen gastrointestinal side effects.
- Engage in gentle exercises if pain permits to aid recovery.
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