Medicine Information

Furex

Name: Furex
Brand: Furex

Injection750 mgDiureticATC: C03CA01

Generic Name

Furosemide

Manufacturer

Beacon Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
furex 750 mg injection	৳ 130.00	N/A

Description

Overview of the medicine

Furosemide is a potent loop diuretic used to treat fluid retention (edema) associated with congestive heart failure, liver disease, kidney disease, and high blood pressure. This 750 mg injection is typically reserved for severe cases or continuous intravenous infusion where high doses are required for diuresis.

Uses & Indications

Treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including nephrotic syndrome.

Management of hypertension, particularly when associated with fluid retention.

Acute pulmonary edema.

Dosage

Adults

Initial dose 20-40 mg IV, repeated every 6-8 hours. For severe edema, continuous infusion of 750 mg over 24 hours might be used, adjusted based on patient response and urine output.

Elderly

Lower initial doses and slower titration may be required due to increased sensitivity and potential for dehydration and electrolyte imbalance. Close monitoring is essential.

Renal_impairment

Dosage adjustment is often necessary. Higher doses may be required in severe renal failure to achieve adequate diuresis, but careful monitoring of electrolytes and renal function is crucial to avoid ototoxicity and worsening renal function. Doses up to 1500-2000 mg/day have been used in continuous infusion.

How to Take

For intravenous use only. Administer slowly over 1-2 minutes for bolus doses or via continuous infusion at a controlled rate.

Mechanism of Action

Furosemide acts on the thick ascending limb of the loop of Henle in the kidney, inhibiting the Na-K-2Cl cotransporter. This prevents the reabsorption of sodium, potassium, and chloride ions, leading to increased excretion of water, sodium, chloride, and other electrolytes.

Pharmacokinetics

Onset

Within 5 minutes after intravenous administration.

Excretion

Primarily renal excretion (80-90% unchanged in urine).

Half life

Approximately 1-1.5 hours in healthy adults, prolonged in renal impairment.

Absorption

Rapidly absorbed after intravenous administration, 100% bioavailability.

Metabolism

Minimally metabolized; primarily excreted unchanged.

Side Effects

Contraindications

Anuria (absence of urine production).
Hypersensitivity to furosemide or sulfonamides.
Hepatic coma or precoma.
Severe electrolyte depletion.

Drug Interactions

NSAIDs

May reduce diuretic and antihypertensive effects, increased risk of renal toxicity.

Digoxin

Increased risk of digitalis toxicity due to hypokalemia.

Lithium

Increased lithium levels due to reduced renal clearance.

Corticosteroids

Increased risk of hypokalemia.

Aminoglycoside antibiotics

Increased risk of ototoxicity.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Symptoms include dehydration, electrolyte imbalance (hypokalemia, hyponatremia, hypochloremia, metabolic alkalosis), hypovolemia, hypotension, and cardiovascular collapse. Management involves fluid and electrolyte replacement, and symptomatic and supportive care.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Furosemide is excreted in breast milk and may inhibit lactation; caution is advised during breastfeeding.

Side Effects

Contraindications

Anuria (absence of urine production).
Hypersensitivity to furosemide or sulfonamides.
Hepatic coma or precoma.
Severe electrolyte depletion.

Drug Interactions

NSAIDs

May reduce diuretic and antihypertensive effects, increased risk of renal toxicity.

Digoxin

Increased risk of digitalis toxicity due to hypokalemia.

Lithium

Increased lithium levels due to reduced renal clearance.

Corticosteroids

Increased risk of hypokalemia.

Aminoglycoside antibiotics

Increased risk of ototoxicity.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Furosemide is excreted in breast milk and may inhibit lactation; caution is advised during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 mL ampoule (75 mg/mL, total 750 mg)5 x 10 mL ampoules

Shelf Life

24-36 months from manufacturing date, typically as indicated on the packaging.

Availability

Hospitals, Clinics, Pharmacies

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied since its introduction in the 1960s. Numerous clinical trials support its efficacy in treating edema and hypertension.

Lab Monitoring

Serum electrolytes (sodium, potassium, chloride, magnesium, calcium) regularly.
Renal function (creatinine, BUN).
Blood pressure and heart rate.

Doctor Notes

Monitor fluid status, electrolytes, and renal function closely, particularly in patients receiving high doses or with pre-existing renal impairment. Consider continuous infusion for optimal diuresis in severe cases.
Beware of potential drug interactions, especially with aminoglycosides and lithium. Educate patients on symptoms of dehydration and electrolyte imbalance.

Patient Guidelines

Report any signs of dehydration (e.g., extreme thirst, dry mouth, decreased urination) or electrolyte imbalance (e.g., muscle weakness, cramps, irregular heartbeat).
Avoid sudden changes in posture to prevent dizziness.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness or lightheadedness, especially at the start of treatment or with dose changes. Avoid driving or operating machinery until you know how Furosemide affects you.