G-Fix
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g fix 100 mg suspension | ৳ 230.00 | N/A |
Description
Overview of the medicine
G-Fix 100 mg Suspension is an oral third-generation cephalosporin antibiotic used to treat a wide variety of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
Typically for pediatric use. For children, the recommended dosage is 8 mg/kg/day orally, either as a single daily dose or in two divided doses for 7-14 days. For adults (if using suspension, not common): 200-400 mg once daily or in two divided doses (e.g., 10-20 ml of 100mg/5ml suspension).
Elderly
No specific dosage adjustment required for elderly patients with normal renal function.
Renal_impairment
Dose adjustment required. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
Administer orally with or without food. Shake the suspension well before each use. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan, essential for bacterial cell wall strength and rigidity. This leads to the lysis and death of susceptible bacteria.
Pharmacokinetics
Onset
Not specified, but antibacterial effect usually within hours.
Excretion
Primarily excreted unchanged in urine (about 50-60% of absorbed dose) and also some biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized. A small fraction may be metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime use.
Oral contraceptives
May reduce the effectiveness of oral contraceptives (use additional barrier method).
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension at room temperature (15-30°C) for up to 7 days or refrigerate (2-8°C) for up to 14 days. Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime use.
Oral contraceptives
May reduce the effectiveness of oral contraceptives (use additional barrier method).
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension at room temperature (15-30°C) for up to 7 days or refrigerate (2-8°C) for up to 14 days. Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). 7 days (reconstituted suspension) when stored at room temperature, 14 days when refrigerated.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA (USA), DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for approved indications in both adult and pediatric populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (for prolonged therapy)
- Liver function tests (rarely needed, but consider in specific cases)
Doctor Notes
- Consider culture and susceptibility tests to guide therapy if initial empirical treatment fails.
- Educate patients on the importance of completing the full antibiotic course.
- Monitor for signs of allergic reactions, especially in patients with penicillin allergy history.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Do not share this medicine with others.
- Shake suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
G-Fix 100 mg Suspension may cause dizziness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment (though not strictly contraindicated, generally good advice with antibiotics).
- Eat a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in G-Fix Brand
Other medicines available under the same brand name
