G-Fix
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g fix 400 mg capsule | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
G-Fix 400 mg Capsule is an antibiotic medicine containing Cefixime, used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, and ears.
Uses & Indications
Dosage
Adults
Adults: 400 mg once daily or 200 mg every 12 hours, typically for 7-14 days depending on infection severity and type.
Elderly
No specific dose adjustment required unless there is significant renal impairment.
Renal_impairment
CrCl 21-60 mL/min: 300 mg daily. CrCl < 20 mL/min: 200 mg daily.
How to Take
Oral. Can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cefixime is a cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours after oral administration.
Excretion
Primarily excreted unchanged in the urine (about 50%) and also through bile/feces.
Half life
Average 3-4 hours, may be prolonged in renal impairment.
Absorption
Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly affect the total amount absorbed.
Metabolism
Not extensively metabolized; approximately 10% metabolised in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any type of beta-lactam antibacterial agents (e.g., penicillins).
Drug Interactions
Nifedipine
May increase Cefixime peak plasma levels and AUC.
Carbamazepine
Elevated Carbamazepine levels reported with concomitant use.
Oral anticoagulants (e.g., Warfarin)
May increase prothrombin time/INR. Monitor coagulation parameters.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not substantially effective in removing Cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any type of beta-lactam antibacterial agents (e.g., penicillins).
Drug Interactions
Nifedipine
May increase Cefixime peak plasma levels and AUC.
Carbamazepine
Elevated Carbamazepine levels reported with concomitant use.
Oral anticoagulants (e.g., Warfarin)
May increase prothrombin time/INR. Monitor coagulation parameters.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis is not substantially effective in removing Cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various bacterial infections, including respiratory and urinary tract infections, showing good clinical and bacteriological cure rates.
Lab Monitoring
- Renal function in patients with pre-existing renal impairment.
- Coagulation parameters if co-administered with anticoagulants.
Doctor Notes
- Prescribe with caution in patients with a history of gastrointestinal disease, especially colitis.
- Adjust dose in renal impairment according to creatinine clearance.
- Counsel patients on completing the full course to prevent resistance and recurrence.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve, to prevent resistance.
- Do not share this medication with others, even if they have similar symptoms.
- Consult a doctor if side effects persist or worsen, or if signs of a new infection appear.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, does not impair the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated during treatment, especially if experiencing diarrhea.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in G-Fix Brand
Other medicines available under the same brand name
