G-Salbutamol
Generic Name
Salbutamol (as Sulfate)
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g salbutamol 2 mg syrup | ৳ 20.00 | N/A |
Description
Overview of the medicine
Salbutamol is a selective short-acting beta-2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).
Uses & Indications
Dosage
Adults
4 mg (10 ml) 3 or 4 times daily. May be increased to 8 mg (20 ml) if necessary.
Elderly
Initially 2 mg (5 ml) 3 or 4 times daily, increasing if necessary.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment, consult physician.
How to Take
To be taken orally. Can be taken with or without food.
Mechanism of Action
Salbutamol selectively stimulates beta-2 adrenergic receptors primarily located in the bronchial smooth muscle. This stimulation leads to the activation of adenyl cyclase, which increases intracellular cyclic AMP (cAMP) levels. Increased cAMP results in the relaxation of bronchial smooth muscle, leading to bronchodilation.
Pharmacokinetics
Onset
5-15 minutes (oral)
Excretion
Excreted primarily in the urine as metabolites and unchanged drug.
Half life
4-6 hours
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations within 2-3 hours.
Metabolism
Primarily metabolized in the liver to an inactive sulfate conjugate.
Side Effects
Contraindications
- Hypersensitivity to Salbutamol or any component of the syrup
- Threatened abortion during the first or second trimesters of pregnancy
Drug Interactions
Digoxin
May increase serum digoxin levels.
Beta-blockers (e.g., Propranolol)
Can antagonize the effects of Salbutamol and cause severe bronchospasm.
Diuretics (non-potassium-sparing)
May exacerbate hypokalemia when co-administered with high doses of Salbutamol.
Monoamine Oxidase Inhibitors (MAOIs) & Tricyclic Antidepressants (TCAs)
May potentiate the vascular effects of Salbutamol.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremor, headache, hypokalemia, and hyperglycemia. Treatment is symptomatic and supportive; consider cardioselective beta-blockers with caution for cardiac symptoms.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Salbutamol or any component of the syrup
- Threatened abortion during the first or second trimesters of pregnancy
Drug Interactions
Digoxin
May increase serum digoxin levels.
Beta-blockers (e.g., Propranolol)
Can antagonize the effects of Salbutamol and cause severe bronchospasm.
Diuretics (non-potassium-sparing)
May exacerbate hypokalemia when co-administered with high doses of Salbutamol.
Monoamine Oxidase Inhibitors (MAOIs) & Tricyclic Antidepressants (TCAs)
May potentiate the vascular effects of Salbutamol.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include tachycardia, tremor, headache, hypokalemia, and hyperglycemia. Treatment is symptomatic and supportive; consider cardioselective beta-blockers with caution for cardiac symptoms.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Generic, Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of salbutamol for the treatment of asthma and COPD. Specific trials for this generic formulation demonstrate bioequivalence to the innovator product.
Lab Monitoring
- Serum potassium levels (especially in patients receiving high doses or concomitant diuretics)
Doctor Notes
- Emphasize proper administration technique.
- Advise patients not to exceed prescribed doses due to cardiac risks.
- Monitor for hypokalemia, especially in severe cases or co-treatment with diuretics.
Patient Guidelines
- Follow the prescribed dosage strictly.
- Do not exceed the recommended dose.
- Seek medical attention if symptoms worsen or do not improve.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Salbutamol may cause tremor or dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Identify and avoid asthma triggers.
- Maintain good hydration.
- Avoid smoking.
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Global Brand Names
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