Gaspro
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gaspro 20 mg capsule | ৳ 6.35 | ৳ 63.50 |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor (PPI) used to treat conditions caused by excess stomach acid, such as heartburn, gastroesophageal reflux disease (GERD), and ulcers.
Uses & Indications
Dosage
Adults
Typical dosage is 20-40 mg once daily, usually in the morning before food. Duration varies by condition (e.g., 4-8 weeks for ulcers).
Elderly
No general dosage adjustment required, but caution with severe hepatic impairment.
Renal_impairment
No dosage adjustment necessary for patients with impaired renal function.
How to Take
Take the capsule whole with water, preferably in the morning before a meal. Do not chew, crush, or open the capsule.
Mechanism of Action
Omeprazole irreversibly blocks the H+/K+-ATPase (proton pump) in the secretory surface of gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Acid inhibitory effect starts within 1 hour, maximal effect within 2 hours.
Excretion
Approximately 80% is excreted in the urine as metabolites, and the remainder in the feces.
Half life
Plasma half-life is 0.5-1 hour, but acid suppression effect lasts much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 30-40% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver primarily via cytochrome P450 enzymes (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (due to significant reduction in nelfinavir plasma levels).
Drug Interactions
Diazepam
Prolonged elimination of diazepam.
Warfarin
Increased INR and bleeding risk. Monitor INR closely.
Tacrolimus
Increased tacrolimus plasma concentrations. Monitor tacrolimus levels.
Clopidogrel
Reduced antiplatelet effect of clopidogrel. Avoid concomitant use if possible.
Methotrexate
Increased methotrexate levels, potentially leading to toxicity.
Storage
Store in a cool and dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include nausea, vomiting, abdominal pain, diarrhea, headache, and drowsiness. Management is symptomatic and supportive.
Pregnancy & Lactation
Omeprazole is generally considered safe during pregnancy (Category C) and lactation. Use only if clearly needed and after consulting a doctor.
Side Effects
Contraindications
- Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (due to significant reduction in nelfinavir plasma levels).
Drug Interactions
Diazepam
Prolonged elimination of diazepam.
Warfarin
Increased INR and bleeding risk. Monitor INR closely.
Tacrolimus
Increased tacrolimus plasma concentrations. Monitor tacrolimus levels.
Clopidogrel
Reduced antiplatelet effect of clopidogrel. Avoid concomitant use if possible.
Methotrexate
Increased methotrexate levels, potentially leading to toxicity.
Storage
Store in a cool and dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include nausea, vomiting, abdominal pain, diarrhea, headache, and drowsiness. Management is symptomatic and supportive.
Pregnancy & Lactation
Omeprazole is generally considered safe during pregnancy (Category C) and lactation. Use only if clearly needed and after consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established omeprazole's efficacy and safety across various acid-related disorders, demonstrating superior acid suppression compared to H2-receptor antagonists.
Lab Monitoring
- Magnesium levels (with prolonged use, especially >1 year)
- Vitamin B12 levels (with prolonged use, especially >3 years)
Doctor Notes
- Always exclude the presence of gastric malignancy before starting omeprazole therapy, especially in elderly patients with alarm symptoms.
- Use the lowest effective dose for the shortest duration necessary to achieve therapeutic goals.
- Advise patients about potential long-term risks with PPIs and monitor for signs of deficiencies.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Seek medical attention if you experience severe side effects or symptoms worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole may cause dizziness, visual disturbances, or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty, acidic foods, caffeine, alcohol) that worsen your symptoms.
- Eat smaller, more frequent meals instead of large ones.
- Elevate the head of your bed if you suffer from GERD symptoms at night.
- Maintain a healthy weight and avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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