Gaspro
Generic Name
Pantoprazole 40 mg Injection
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gaspro 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Gaspro 40 mg Injection contains Pantoprazole, a proton pump inhibitor, used to reduce stomach acid production for conditions like ulcers and reflux. It is administered intravenously.
Uses & Indications
Dosage
Adults
For GERD: 40 mg once daily. For Zollinger-Ellison Syndrome: Initial 80 mg once daily, adjusted based on acid output. For ulcer rebleeding prevention: 80 mg bolus, then 8 mg/hr continuous infusion for 72 hours.
Elderly
No specific dose adjustment required for elderly patients with normal renal and hepatic function.
Renal_impairment
No dose adjustment necessary for patients with renal impairment.
How to Take
Intravenous administration only. Administer as a slow injection over at least 2 minutes or as a short intravenous infusion over 15 minutes. It should be reconstituted with the provided solvent and further diluted if needed.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, inhibiting the final step of acid secretion.
Pharmacokinetics
Onset
Within 15-30 minutes.
Excretion
Mainly renal (approximately 80%) as metabolites, with the remainder excreted in the feces.
Half life
Approximately 1 hour (terminal elimination half-life for acid suppression effect is longer, 7-9 hours).
Absorption
Rapidly absorbed after intravenous administration, 100% bioavailability.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to pantoprazole or any excipients
- •Hypersensitivity to other substituted benzimidazoles
Drug Interactions
Digoxin
Increased absorption of digoxin due to increased gastric pH.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased plasma levels of methotrexate, especially at high doses, leading to potential toxicity.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of drugs requiring acidic gastric pH.
Atazanavir, Nelfinavir (and other HIV protease inhibitors)
Reduced absorption due to altered gastric pH, potentially leading to loss of virological response.
Storage
Store below 25°C in a dry place, protected from light. Do not freeze. Reconstituted solution should be used within 6 hours at room temperature or 24 hours if refrigerated.
Overdose
Symptoms of overdose are generally unknown. In case of suspected overdose, symptomatic and supportive treatment should be given. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as pantoprazole is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as per manufacturer instructions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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