Gaspro
Generic Name
gaspro-40-mg-capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gaspro 40 mg capsule | ৳ 9.00 | ৳ 54.00 |
Description
Overview of the medicine
Gaspro 40 mg capsule is a proton pump inhibitor used to reduce stomach acid production, treating conditions like heartburn, acid reflux, and ulcers caused by excess acid.
Uses & Indications
Dosage
Adults
Usually 20-40 mg once daily, depending on the condition. For severe GERD, 40 mg daily for 4-8 weeks. For H. pylori eradication, 40 mg once or twice daily with antibiotics.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential for decreased hepatic function.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with water at least 30 minutes before a meal, preferably in the morning. Do not chew or crush.
Mechanism of Action
Omeprazole, a proton pump inhibitor, irreversibly blocks the H+/K+ ATPase enzyme system (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (about 77%) and feces (about 18%) as metabolites.
Half life
0.5-1 hour, but duration of action is longer due to irreversible binding.
Absorption
Rapidly absorbed from the gastrointestinal tract, primarily in the small intestine. Bioavailability is about 30-40%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, particularly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any other components of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Nelfinavir, Atazanavir
Reduced plasma concentrations of antiretrovirals.
Diazepam, Phenytoin, Citalopram
Increased plasma levels of these drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Category C for pregnancy. Use only if potential benefit outweighs potential risk. Small amounts are excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any other components of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Nelfinavir, Atazanavir
Reduced plasma concentrations of antiretrovirals.
Diazepam, Phenytoin, Citalopram
Increased plasma levels of these drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Category C for pregnancy. Use only if potential benefit outweighs potential risk. Small amounts are excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various acid-related disorders.
Lab Monitoring
- Monitor magnesium levels with prolonged use
- Monitor INR for patients on warfarin
Doctor Notes
- Advise patients to report persistent or recurrent symptoms.
- Consider magnesium supplementation for long-term users.
- Evaluate for underlying causes of dyspepsia or reflux before initiating PPI therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy, fatty, and acidic foods.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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