gbpoietin
Generic Name
Epoetin Alfa 10000 IU Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gbpoietin 10000 iu injection | ৳ 5,149.91 | N/A |
Description
Overview of the medicine
Epoetin Alfa is a recombinant human erythropoietin, a glycoprotein that stimulates red blood cell production. It is used to treat anemia associated with chronic kidney disease, chemotherapy, or certain surgical procedures.
Uses & Indications
Dosage
Adults
Initial dose typically 50-100 IU/kg three times weekly (IV or SC), adjusted to maintain target hemoglobin levels (e.g., 10-12 g/dL).
Elderly
No specific dose adjustments needed for elderly patients unless they have severe comorbidities; dosage is individualized based on response.
Renal_impairment
Used to treat anemia in CKD patients; dosage is based on hemoglobin response and target levels.
How to Take
Administer by intravenous (IV) or subcutaneous (SC) injection. The route of administration depends on the indication and patient's condition. Do not shake the syringe. Do not use if solution is cloudy or contains particulate matter.
Mechanism of Action
Epoetin Alfa acts like natural erythropoietin, binding to erythropoietin receptors on progenitor cells in the bone marrow, stimulating erythropoiesis (red blood cell production) and differentiation.
Pharmacokinetics
Onset
Reticulocytosis typically occurs within 7-10 days, with hemoglobin increase observed over 2-6 weeks.
Excretion
Minor renal excretion of intact drug; primary clearance is metabolic/receptor-mediated.
Half life
Intravenous: Approximately 4-13 hours. Subcutaneous: Approximately 13-24 hours.
Absorption
Subcutaneous (SC) administration leads to slower absorption and lower peak concentration compared to intravenous (IV) administration. Bioavailability for SC is 30-40%.
Metabolism
Primarily cleared via receptor-mediated endocytosis by erythroid progenitor cells and to a lesser extent by the liver and kidneys.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Known hypersensitivity to mammalian cell-derived products or any component of the product.
- Patients who develop pure red cell aplasia (PRCA) after treatment with any erythropoietin protein.
Drug Interactions
Iron Supplements
Concomitant iron supplementation is usually required to support erythropoiesis, especially when iron stores are low.
Other Hematopoietic Growth Factors
Use with caution due to potential additive effects.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdose can lead to polycythemia, which may require phlebotomy to maintain hemoglobin levels within the target range. Monitor blood pressure and other vital signs closely.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Known hypersensitivity to mammalian cell-derived products or any component of the product.
- Patients who develop pure red cell aplasia (PRCA) after treatment with any erythropoietin protein.
Drug Interactions
Iron Supplements
Concomitant iron supplementation is usually required to support erythropoiesis, especially when iron stores are low.
Other Hematopoietic Growth Factors
Use with caution due to potential additive effects.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdose can lead to polycythemia, which may require phlebotomy to maintain hemoglobin levels within the target range. Monitor blood pressure and other vital signs closely.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired; biosimilars available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety in various indications, with ongoing post-marketing surveillance and studies on long-term outcomes.
Lab Monitoring
- Hemoglobin and hematocrit levels (regularly)
- Iron status (serum ferritin, transferrin saturation)
- Blood pressure (before and during treatment)
Doctor Notes
- Individualize dose to achieve and maintain hemoglobin levels within the target range (e.g., 10-12 g/dL) to minimize risks.
- Monitor blood pressure frequently and manage hypertension aggressively.
- Assess iron status before and during treatment; iron supplementation is often critical for optimal response.
Patient Guidelines
- Do not adjust your dose or stop treatment without consulting your doctor.
- Report any sudden severe headaches, visual changes, or signs of blood clots immediately.
- Ensure adequate iron intake as advised by your healthcare provider.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine is not expected to impair your ability to drive or operate machinery. However, if you experience side effects like seizures, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet rich in iron, discuss exercise routines with your doctor, and manage underlying conditions like hypertension.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in gbpoietin Brand
Other medicines available under the same brand name
