gbpoietin
Generic Name
gbpoietin-4000-iu-injection
Manufacturer
Generic Biopharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gbpoietin 4000 iu injection | ৳ 2,650.12 | N/A |
Description
Overview of the medicine
Gbpoietin is an erythropoiesis-stimulating agent (ESA) used to treat anemia. It helps increase red blood cell production in patients with chronic kidney disease, chemotherapy-induced anemia, or certain HIV treatments.
Uses & Indications
Dosage
Adults
Dosage varies by indication and route (IV/SC). For CKD, initial dose is typically 50-100 IU/kg three times per week. Adjust dose based on hemoglobin response and target levels.
Elderly
Similar dosage to adults, but monitor closely for side effects and comorbidities.
Renal_impairment
Primary indication for CKD-associated anemia. Dosage adjusted based on individual response and target hemoglobin levels.
How to Take
Administer intravenously (IV) or subcutaneously (SC). Do not shake the syringe. Use a single dose per vial/syringe.
Mechanism of Action
It stimulates erythropoiesis by binding to the erythropoietin receptor on erythroid progenitor cells, leading to their proliferation and differentiation into mature red blood cells.
Pharmacokinetics
Onset
Hematologic response typically observed within 2-6 weeks for full effect.
Excretion
Primarily excreted renally, with some biliary excretion.
Half life
IV: Approximately 4-13 hours; SC: Approximately 19-24 hours.
Absorption
Slow absorption following subcutaneous (SC) administration; immediate onset after intravenous (IV) administration.
Metabolism
Primarily metabolized in the liver (reticuloendothelial system) through proteolysis.
Side Effects
Contraindications
- •Uncontrolled hypertension.
- •Pure red cell aplasia (PRCA) unrelated to ESAs.
Drug Interactions
Iron supplements
Erythropoietin increases iron utilization, requiring iron supplementation to support erythropoiesis.
Other hematopoietic agents
No known direct interactions, but concurrent use should be monitored.
Storage
Store refrigerated between 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdose can lead to polycythemia (excessive red blood cells). Treatment involves phlebotomy (blood withdrawal) to reduce hematocrit and symptomatic/supportive care.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Unknown if excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored correctly.
Availability
Hospitals and pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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