geflox
Generic Name
Cefixime 250 mg Suspension
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| geflox 250 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Geflox 250 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic, effective against a wide range of gram-positive and gram-negative bacteria. It is used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Not typically used for adults in suspension form; adults usually take 200-400 mg daily as tablets/capsules.
Children
For children 6 months to 12 years: 8 mg/kg/day administered as a single dose or in two divided doses for 5 to 10 days, depending on the infection. Max dose 400 mg/day.
Renal_impairment
Dosage adjustment required for creatinine clearance < 30 ml/min; reduce dose by 50%.
How to Take
Oral administration. Shake the suspension well before each use. Can be taken with or without food. Complete the full course of treatment as prescribed by the doctor.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. This leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours.
Excretion
Primarily excreted by the kidneys (glomerular filtration and tubular secretion) and also via biliary/fecal route.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized; about 10% of orally administered dose is excreted as unchanged drug in urine.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase Cefixime plasma levels.
Probenecid
May increase Cefixime plasma levels by decreasing renal excretion.
Carbamazepine
Concomitant use may increase carbamazepine plasma concentrations.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time; monitor INR closely.
Storage
Store dry powder below 30°C in a dry place, protected from light. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-14 days.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Cefixime is excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase Cefixime plasma levels.
Probenecid
May increase Cefixime plasma levels by decreasing renal excretion.
Carbamazepine
Concomitant use may increase carbamazepine plasma concentrations.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time; monitor INR closely.
Storage
Store dry powder below 30°C in a dry place, protected from light. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-14 days.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Cefixime is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years for dry powder; 7-14 days after reconstitution when stored as directed.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Cefixime's efficacy and safety for approved indications. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Monitor renal function in patients with pre-existing renal impairment.
- Monitor prothrombin time/INR in patients concurrently taking anticoagulants.
Doctor Notes
- Advise parents on proper measurement and administration of suspension.
- Emphasize completing the full course to prevent resistance.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve.
- Shake the suspension well before each use.
- Store at room temperature away from moisture and direct light.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid self-medication and consult a doctor for any persistent symptoms.
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