HCG
Generic Name
Human Chorionic Gonadotropin (HCG) 10000 IU
Manufacturer
Various Pharmaceutical Companies
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hcg 10000 iu injection | ৳ 4,000.00 | N/A |
Description
Overview of the medicine
Human Chorionic Gonadotropin (HCG) is a hormone produced by the placenta during pregnancy. In medicine, it's used to treat female infertility, male hypogonadism, and cryptorchidism in prepubescent boys. It mimics Luteinizing Hormone (LH) to stimulate ovulation or testosterone production.
Uses & Indications
Dosage
Adults
Female: 5,000 to 10,000 IU via IM or SC injection, usually 1 day after the last dose of menotropins or FSH. Male hypogonadism: 500 to 4,000 IU, 3 times per week for 6-9 months, followed by maintenance if needed.
Elderly
Use with caution; dosage may need adjustment based on renal/hepatic function, though HCG is not primarily used in the elderly population for its main indications.
Renal_impairment
No specific dose adjustment guidelines; use with caution. HCG is primarily metabolized by the liver.
How to Take
Administered as an intramuscular (IM) or subcutaneous (SC) injection after reconstitution of the powder with the supplied solvent. Ensure proper sterile technique.
Mechanism of Action
HCG binds to the LH/CG receptor in the gonads and mimics the action of endogenous Luteinizing Hormone (LH), stimulating steroidogenesis in the corpus luteum (women) and Leydig cells (men), leading to ovulation or testosterone production, respectively.
Pharmacokinetics
Onset
Effects on ovulation typically within 36 hours; hormonal responses over days/weeks for other indications.
Excretion
Excreted predominantly by the kidneys.
Half life
Approximately 24-48 hours.
Absorption
Rapidly absorbed after intramuscular (IM) or subcutaneous (SC) injection.
Metabolism
Primarily hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to HCG or any excipients.
- Precocious puberty (unless for cryptorchidism).
- Prostate carcinoma or other androgen-dependent neoplasms in males.
- Untreated thyroid or adrenal dysfunction.
- Primary ovarian failure (women) or primary testicular failure (men).
- Uncontrolled ovarian cysts or polycystic ovary syndrome (PCOS) (for certain uses).
- Thrombophlebitis or active thromboembolic disorders.
Drug Interactions
Other hormones
Interactions with other hormonal preparations are possible and should be monitored.
GnRH agonists/antagonists
May require adjustment of HCG dosage when used in conjunction with other fertility treatments.
Storage
Store unopened vials in the refrigerator at 2°C to 8°C (36°F to 46°F), protected from light. Do not freeze. After reconstitution, store in the refrigerator and use within the specified timeframe.
Overdose
Overdose primarily presents as severe Ovarian Hyperstimulation Syndrome (OHSS) in women. Management is symptomatic and supportive, including hospitalization if severe, fluid and electrolyte management, and monitoring for complications like thromboembolism.
Pregnancy & Lactation
Pregnancy: HCG is used in specific assisted reproductive technologies, but is contraindicated for other uses during pregnancy. Lactation: Not recommended during breastfeeding due to lack of data and potential for hormonal effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to HCG or any excipients.
- Precocious puberty (unless for cryptorchidism).
- Prostate carcinoma or other androgen-dependent neoplasms in males.
- Untreated thyroid or adrenal dysfunction.
- Primary ovarian failure (women) or primary testicular failure (men).
- Uncontrolled ovarian cysts or polycystic ovary syndrome (PCOS) (for certain uses).
- Thrombophlebitis or active thromboembolic disorders.
Drug Interactions
Other hormones
Interactions with other hormonal preparations are possible and should be monitored.
GnRH agonists/antagonists
May require adjustment of HCG dosage when used in conjunction with other fertility treatments.
Storage
Store unopened vials in the refrigerator at 2°C to 8°C (36°F to 46°F), protected from light. Do not freeze. After reconstitution, store in the refrigerator and use within the specified timeframe.
Overdose
Overdose primarily presents as severe Ovarian Hyperstimulation Syndrome (OHSS) in women. Management is symptomatic and supportive, including hospitalization if severe, fluid and electrolyte management, and monitoring for complications like thromboembolism.
Pregnancy & Lactation
Pregnancy: HCG is used in specific assisted reproductive technologies, but is contraindicated for other uses during pregnancy. Lactation: Not recommended during breastfeeding due to lack of data and potential for hormonal effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Varies by manufacturer, typically 2-3 years for unopened vials when stored correctly. Reconstituted solution generally stable for 28 days if refrigerated.
Availability
Available in hospitals and pharmacies globally
Approval Status
Historically approved by major regulatory bodies (e.g., FDA)
Patent Status
Generic, no active patent for the molecule
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established HCG's efficacy and safety in various fertility treatments and for cryptorchidism. Ongoing research explores optimized dosing regimens and combination therapies.
Lab Monitoring
- Serum HCG levels (if indicated).
- Serum estradiol and progesterone levels (in women undergoing fertility treatment).
- Ultrasound monitoring for follicular development and ovarian size (in women).
- Serum testosterone levels (in men with hypogonadism).
- Liver and kidney function tests (periodically, especially with long-term use).
Doctor Notes
- Careful patient selection and individualized dosing are crucial to optimize outcomes and minimize risks, particularly OHSS.
- Strict monitoring of ovarian response (ultrasound, estradiol levels) is essential during controlled ovarian stimulation.
- Educate patients thoroughly on potential side effects, self-administration technique, and when to seek immediate medical attention.
Patient Guidelines
- Follow your doctor's dosage and administration instructions precisely.
- Learn proper injection technique from a healthcare professional.
- Report any unusual symptoms, especially severe abdominal pain or swelling, immediately.
- Do not use HCG for weight loss or other unapproved indications.
Missed Dose Advice
Contact your doctor or fertility specialist immediately if a dose is missed. Do not double the next dose.
Driving Precautions
Generally no impact on driving ability. However, if you experience dizziness or visual disturbances as a side effect, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and lifestyle as advised by your healthcare provider to support fertility outcomes.
- Avoid strenuous physical activity if OHSS symptoms develop.
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