HCG
Generic Name
Human Chorionic Gonadotropin (HCG) 5000 IU Injection
Manufacturer
Various Pharmaceutical Companies
Country
Global / Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hcg 5000 iu injection | ৳ 2,300.00 | N/A |
Description
Overview of the medicine
HCG is a hormone produced by the placenta during pregnancy. It is used in medicine to stimulate ovulation in women, treat cryptorchidism and hypogonadism in males, and for assisted reproductive technologies.
Uses & Indications
Dosage
Adults
Female Infertility: 5,000 to 10,000 IU one day following the last dose of menotropins or FSH. Male Hypogonadism: 500-4,000 IU, 2-3 times per week, for several weeks or months, often combined with FSH.
Elderly
Use with caution; no specific dose adjustments generally recommended, but individual assessment is important.
Renal_impairment
No specific dose adjustments are provided; use with caution and monitor for adverse effects due to potential altered excretion.
How to Take
Administered by intramuscular (IM) or subcutaneous (SC) injection after reconstitution with the provided diluent. Must be administered by a healthcare professional.
Mechanism of Action
Human Chorionic Gonadotropin (HCG) mimics the action of Luteinizing Hormone (LH). In women, it triggers the final maturation of ovarian follicles and induces ovulation. In men, it stimulates the Leydig cells in the testes to produce androgens, particularly testosterone.
Pharmacokinetics
Onset
Effects on steroidogenesis seen within hours; ovulation typically occurs 36-40 hours post-administration.
Excretion
Mainly excreted in the urine as intact hormone and its metabolites.
Half life
Approximately 29-30 hours (biphasic elimination, initial phase ~11 hours, terminal phase ~29-30 hours).
Absorption
Rapidly absorbed after intramuscular (IM) or subcutaneous (SC) injection.
Metabolism
Primarily metabolized in the liver and kidneys.
Side Effects
Contraindications
- Hypersensitivity to HCG or any excipients.
- Known or suspected androgen-dependent tumors (e.g., prostate carcinoma in males).
- Precocious puberty (in males, when used for cryptorchidism).
- Primary gonadal failure (e.g., primary ovarian insufficiency or primary testicular failure).
- Uncontrolled thyroid or adrenal dysfunction.
- Ectopic pregnancy within the previous 3 months.
Drug Interactions
No significant drug interactions
No clinically significant drug interactions have been widely reported for HCG. However, concurrent use of other fertility drugs should be closely monitored by a physician.
Storage
Store at 2°C to 8°C (refrigerate). Protect from light. Do not freeze. After reconstitution, the solution should be used immediately.
Overdose
Overdose can lead to Ovarian Hyperstimulation Syndrome (OHSS) in women, characterized by severe abdominal pain, bloating, nausea, vomiting, and fluid accumulation. In males, symptoms may include gynecomastia, headache, or abdominal pain. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Contraindicated except for specific diagnostic uses; should not be used for weight loss during pregnancy. Lactation: It is unknown whether HCG is excreted in human milk. Caution should be exercised, and a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to HCG or any excipients.
- Known or suspected androgen-dependent tumors (e.g., prostate carcinoma in males).
- Precocious puberty (in males, when used for cryptorchidism).
- Primary gonadal failure (e.g., primary ovarian insufficiency or primary testicular failure).
- Uncontrolled thyroid or adrenal dysfunction.
- Ectopic pregnancy within the previous 3 months.
Drug Interactions
No significant drug interactions
No clinically significant drug interactions have been widely reported for HCG. However, concurrent use of other fertility drugs should be closely monitored by a physician.
Storage
Store at 2°C to 8°C (refrigerate). Protect from light. Do not freeze. After reconstitution, the solution should be used immediately.
Overdose
Overdose can lead to Ovarian Hyperstimulation Syndrome (OHSS) in women, characterized by severe abdominal pain, bloating, nausea, vomiting, and fluid accumulation. In males, symptoms may include gynecomastia, headache, or abdominal pain. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Contraindicated except for specific diagnostic uses; should not be used for weight loss during pregnancy. Lactation: It is unknown whether HCG is excreted in human milk. Caution should be exercised, and a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, but refer to the manufacturer's specific packaging and expiry date.
Availability
Pharmacies, hospitals, fertility clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent (Generic)
Clinical Trials
Ongoing clinical trials evaluate HCG's role in various fertility protocols, diagnostic applications, and its potential in other therapeutic areas, though its primary uses are well-established.
Lab Monitoring
- Serum estradiol levels (women)
- Serum progesterone levels (women)
- Ultrasound for follicular development (women)
- Serum testosterone levels (men)
- Semen analysis (men)
Doctor Notes
- Careful monitoring of ovarian response (ultrasound and estradiol levels) is crucial to minimize the risk of OHSS and multiple gestations.
- Thorough patient education on administration, potential side effects, and warning signs of OHSS is essential.
- In males, treatment duration may vary; monitor testosterone levels and semen analysis as appropriate.
Patient Guidelines
- Follow your doctor's instructions strictly regarding dose and administration schedule.
- Report any severe abdominal pain, bloating, or sudden weight gain immediately to your doctor.
- Be aware of the potential for multiple pregnancies and discuss it with your healthcare provider.
- Store the medication as directed and do not use if expired.
Missed Dose Advice
If a dose is missed, contact your doctor or healthcare provider immediately for advice. Do not double the dose.
Driving Precautions
HCG is not known to directly impair the ability to drive or operate machinery. However, if you experience side effects like headache, dizziness, or mood changes, exercise caution.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet and moderate exercise, as advised by your doctor.
- Avoid strenuous physical activity if you experience symptoms of Ovarian Hyperstimulation Syndrome (OHSS).
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