HCG
Generic Name
Human Chorionic Gonadotropin
Manufacturer
Multiple manufacturers globally
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hcg 2500 iu injection | ৳ 1,200.00 | N/A |
Description
Overview of the medicine
HCG (Human Chorionic Gonadotropin) is a hormone produced naturally during pregnancy. In medicine, it is used as an injection to stimulate ovulation in women undergoing fertility treatment and to treat hypogonadism in men. It mimics the action of Luteinizing Hormone (LH).
Uses & Indications
Dosage
Adults
For ovulation induction: 5,000 to 10,000 IU one day following the last dose of menotropins or follitropins. For hypogonadism in males: 500-1000 IU three times per week for 3 weeks, followed by 500-1000 IU three times per week for 6 weeks, often in conjunction with hMG. Dosage for specific conditions and patient response varies, consult physician.
Elderly
Use with caution in elderly males with cardiac or renal impairment due to potential for fluid retention.
Renal_impairment
No specific dose adjustments provided; use with caution due to renal metabolism and excretion.
How to Take
Administered by intramuscular (IM) or subcutaneous (SC) injection after reconstitution with the provided solvent. Follow healthcare provider's instructions carefully for self-administration if prescribed.
Mechanism of Action
HCG binds to the luteinizing hormone (LH)/chorionic gonadotropin receptor of granulosa cells and Leydig cells, stimulating ovarian follicular development and ovulation in women, and testosterone production in the testes of men.
Pharmacokinetics
Onset
Ovulation typically occurs 36-40 hours after administration.
Excretion
Excreted mainly in the urine.
Half life
Approximately 29-36 hours.
Absorption
Rapidly absorbed following intramuscular (IM) or subcutaneous (SC) injection.
Metabolism
Metabolized primarily in the kidneys.
Side Effects
Contraindications
- Hypersensitivity to HCG or any component of the formulation.
- Precocious puberty, prostate carcinoma or other androgen-dependent neoplasms in males.
- Uncontrolled thyroid or adrenal dysfunction.
- Primary ovarian failure (as HCG requires functional ovaries).
- Known or suspected hormone-dependent tumors.
Drug Interactions
No significant drug interactions reported
HCG is generally not associated with significant drug-drug interactions. However, always inform your doctor about all medications you are taking.
Storage
Store lyophilized powder in the refrigerator (2°C-8°C). After reconstitution, use immediately or store refrigerated for a specified period (e.g., 24 hours, check specific product label). Do not freeze.
Overdose
Overdose symptoms may include severe Ovarian Hyperstimulation Syndrome (OHSS), which can manifest as abdominal pain, bloating, nausea, vomiting, diarrhea, rapid weight gain, and shortness of breath. Seek immediate medical attention if overdose is suspected.
Pregnancy & Lactation
HCG is used to induce pregnancy. Once pregnancy is confirmed, its use is generally discontinued. Not recommended during breastfeeding as it is not known if HCG is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to HCG or any component of the formulation.
- Precocious puberty, prostate carcinoma or other androgen-dependent neoplasms in males.
- Uncontrolled thyroid or adrenal dysfunction.
- Primary ovarian failure (as HCG requires functional ovaries).
- Known or suspected hormone-dependent tumors.
Drug Interactions
No significant drug interactions reported
HCG is generally not associated with significant drug-drug interactions. However, always inform your doctor about all medications you are taking.
Storage
Store lyophilized powder in the refrigerator (2°C-8°C). After reconstitution, use immediately or store refrigerated for a specified period (e.g., 24 hours, check specific product label). Do not freeze.
Overdose
Overdose symptoms may include severe Ovarian Hyperstimulation Syndrome (OHSS), which can manifest as abdominal pain, bloating, nausea, vomiting, diarrhea, rapid weight gain, and shortness of breath. Seek immediate medical attention if overdose is suspected.
Pregnancy & Lactation
HCG is used to induce pregnancy. Once pregnancy is confirmed, its use is generally discontinued. Not recommended during breastfeeding as it is not known if HCG is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Varies by manufacturer, typically 2-3 years when stored unopened in refrigerator.
Availability
Pharmacies, specialty clinics, hospitals
Approval Status
Widely approved globally (e.g., FDA, EMA, DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established HCG's efficacy in fertility treatments and male hypogonadism. Ongoing research may explore new applications or improved formulations.
Lab Monitoring
- Serum estradiol levels (during ovulation induction)
- Progesterone levels (post-ovulation)
- Ultrasound monitoring of follicular development and ovarian size (during ovulation induction)
- Testosterone levels (in males with hypogonadism)
Doctor Notes
- Counsel patients thoroughly on the risks of OHSS and multiple gestations.
- Strictly adhere to monitoring protocols (ultrasound, hormone levels) during ovulation induction.
- Ensure proper patient selection and exclusion of contraindications before initiating therapy.
Patient Guidelines
- Follow your doctor's instructions precisely regarding dosage and administration.
- Report any signs of severe abdominal pain, bloating, or rapid weight gain immediately.
- Understand the risks of multiple gestations and Ovarian Hyperstimulation Syndrome (OHSS).
- Do not share needles or medication.
Missed Dose Advice
Contact your doctor or fertility specialist immediately for advice. Do not double the dose to catch up.
Driving Precautions
HCG is not known to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or headache, avoid driving.
Lifestyle Advice
- Avoid strenuous physical activity if OHSS is suspected or diagnosed.
- Maintain adequate hydration as advised by your doctor.
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