Imigra
Generic Name
imigra-10-mg-capsule
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| imigra 10 mg capsule | ৳ 5.02 | ৳ 50.20 |
Description
Overview of the medicine
Imigra 10 mg Capsule is used for the acute treatment of migraine attacks, with or without aura. It helps to relieve migraine symptoms like headache, nausea, and sensitivity to light and sound.
Uses & Indications
Dosage
Adults
The usual recommended dose is 10 mg taken as a single dose at the onset of a migraine headache. If symptoms return, a second dose may be taken after 2 hours. Maximum 20 mg in 24 hours.
Elderly
Use with caution. Dosage adjustments may be considered due to potential age-related decline in renal or hepatic function.
Renal_impairment
No specific dosage adjustment required for mild to moderate renal impairment, but use with caution. Not recommended for severe impairment.
How to Take
Take the capsule whole with water. It can be taken with or without food. Do not chew or crush the capsule.
Mechanism of Action
Imigra acts as a selective agonist for serotonin 5-HT1B and 5-HT1D receptors. It causes vasoconstriction of cranial blood vessels, inhibits pro-inflammatory neuropeptide release, and inhibits pain signal transmission in the trigeminal pathway, leading to migraine relief.
Pharmacokinetics
Onset
Onset of action typically within 30 minutes.
Excretion
Excreted mainly via urine (both unchanged drug and metabolites).
Half life
Approximately 2 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized by monoamine oxidase A (MAO-A).
Side Effects
Contraindications
- Ischemic heart disease (angina pectoris, myocardial infarction, silent ischemia)
- History of stroke or transient ischemic attack (TIA)
- Peripheral vascular disease
- Uncontrolled hypertension
- Severe hepatic impairment
- Concomitant use with ergotamine-containing or ergot-type drugs, or other triptans
- Concomitant use with MAO inhibitors (within 2 weeks of discontinuing MAOI)
Drug Interactions
SSRIs/SNRIs
Increased risk of serotonin syndrome. Monitor patients.
MAO inhibitors
May increase Imigra exposure. Contraindicated.
Other triptans
Increased risk of vasospasm. Avoid concomitant use within 24 hours.
Ergotamine-containing drugs
Increased risk of vasospasm. Avoid concomitant use within 24 hours.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, vomiting, dizziness, and fatigue. Treatment is symptomatic and supportive, with monitoring of vital signs and cardiac function.
Pregnancy & Lactation
Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Ischemic heart disease (angina pectoris, myocardial infarction, silent ischemia)
- History of stroke or transient ischemic attack (TIA)
- Peripheral vascular disease
- Uncontrolled hypertension
- Severe hepatic impairment
- Concomitant use with ergotamine-containing or ergot-type drugs, or other triptans
- Concomitant use with MAO inhibitors (within 2 weeks of discontinuing MAOI)
Drug Interactions
SSRIs/SNRIs
Increased risk of serotonin syndrome. Monitor patients.
MAO inhibitors
May increase Imigra exposure. Contraindicated.
Other triptans
Increased risk of vasospasm. Avoid concomitant use within 24 hours.
Ergotamine-containing drugs
Increased risk of vasospasm. Avoid concomitant use within 24 hours.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, vomiting, dizziness, and fatigue. Treatment is symptomatic and supportive, with monitoring of vital signs and cardiac function.
Pregnancy & Lactation
Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved for prescription use
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of triptans, including those with similar mechanisms to Imigra, in the acute treatment of migraine. Further specific trials for Imigra 10 mg capsule would confirm its profile.
Lab Monitoring
- No routine lab monitoring is generally required for Imigra. However, blood pressure monitoring is important in patients with hypertension.
Doctor Notes
- Prescribe for acute migraine only, not for prophylaxis.
- Educate patients on proper use and warning signs of medication overuse headache.
- Assess cardiovascular risk factors before prescribing.
Patient Guidelines
- Take Imigra as soon as migraine symptoms begin.
- Do not take more than two doses in 24 hours.
- Consult your doctor if your migraine worsens or does not improve.
Missed Dose Advice
Imigra is taken as needed for a migraine attack. It is not for regular daily use. If you forget to take a dose for an existing migraine, take it as soon as you remember, but do not exceed the maximum daily dose.
Driving Precautions
Imigra may cause dizziness or drowsiness. Patients should be advised to assess their ability to perform tasks requiring mental alertness, such as driving or operating machinery, after taking the medication.
Lifestyle Advice
- Identify and avoid migraine triggers.
- Maintain a regular sleep schedule.
- Manage stress through relaxation techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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