Imigra
Generic Name
Sumatriptan
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| imigra 5 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Imigra 5 mg Tablet contains Sumatriptan, a selective serotonin 5-HT1B/1D receptor agonist, used for the acute treatment of migraine attacks with or without aura, and cluster headaches. It helps to relieve migraine symptoms like headache, nausea, and sensitivity to light and sound.
Uses & Indications
Dosage
Adults
One 5 mg tablet taken at the first sign of a migraine attack. If symptoms recur, a second 5 mg tablet may be taken after at least 2 hours, not exceeding a total of 10 mg (two 5 mg tablets) in any 24-hour period. For this specific 5 mg formulation, adhere to physician's advice.
Elderly
Not generally recommended for patients over 65 years of age due to increased risk of cardiovascular events, unless benefits outweigh risks and under strict medical supervision. If used, lowest effective dose should be considered.
Renal_impairment
No dosage adjustment required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take the tablet whole with water. Do not crush, chew, or split the tablet. It can be taken with or without food.
Mechanism of Action
Sumatriptan acts as a selective agonist for 5-HT1B/1D receptors, primarily located on cranial blood vessels and nerve terminals. It causes vasoconstriction of cranial blood vessels, which are dilated during a migraine attack, and inhibits the release of pro-inflammatory neuropeptides from trigeminal nerve endings, thereby alleviating migraine symptoms.
Pharmacokinetics
Onset
Typically within 30-60 minutes after oral administration.
Excretion
Mainly excreted in urine as the inactive metabolite and unchanged drug.
Half life
Approximately 2 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability is about 15% due to first-pass metabolism.
Metabolism
Primarily metabolized by monoamine oxidase A (MAO-A) to an inactive indole acetic acid analogue.
Side Effects
Contraindications
- Ischaemic heart disease (angina pectoris, myocardial infarction, silent ischaemia)
- Prinzmetal's angina
- Previous transient ischaemic attack (TIA) or stroke
- Peripheral vascular disease
- Uncontrolled hypertension
- Severe hepatic impairment
- Concomitant use of MAO inhibitors (within 2 weeks)
- Concomitant use of ergotamine or ergotamine derivatives (within 24 hours)
- Concomitant use of other 5-HT1 agonists
Drug Interactions
SSRIs/SNRIs
Potential for serotonin syndrome. Use with caution.
MAO Inhibitors
Increased systemic exposure to sumatriptan. Contraindicated.
Other 5-HT1 agonists
Additive vasoconstrictor effects. Contraindicated within 24 hours.
Ergotamine-containing preparations
Prolonged vasospastic reactions. Contraindicated within 24 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, respiratory depression, cyanosis, and salivation. Treatment is symptomatic and supportive. Monitor vital signs and ECG.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Limited human data available. Lactation: Sumatriptan is excreted in breast milk. Advise breastfeeding mothers to wait 12 hours after taking sumatriptan before breastfeeding again.
Side Effects
Contraindications
- Ischaemic heart disease (angina pectoris, myocardial infarction, silent ischaemia)
- Prinzmetal's angina
- Previous transient ischaemic attack (TIA) or stroke
- Peripheral vascular disease
- Uncontrolled hypertension
- Severe hepatic impairment
- Concomitant use of MAO inhibitors (within 2 weeks)
- Concomitant use of ergotamine or ergotamine derivatives (within 24 hours)
- Concomitant use of other 5-HT1 agonists
Drug Interactions
SSRIs/SNRIs
Potential for serotonin syndrome. Use with caution.
MAO Inhibitors
Increased systemic exposure to sumatriptan. Contraindicated.
Other 5-HT1 agonists
Additive vasoconstrictor effects. Contraindicated within 24 hours.
Ergotamine-containing preparations
Prolonged vasospastic reactions. Contraindicated within 24 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, respiratory depression, cyanosis, and salivation. Treatment is symptomatic and supportive. Monitor vital signs and ECG.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Limited human data available. Lactation: Sumatriptan is excreted in breast milk. Advise breastfeeding mothers to wait 12 hours after taking sumatriptan before breastfeeding again.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24 to 36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
Clinical Trials
Numerous clinical trials have established the efficacy and safety of sumatriptan for the acute treatment of migraine and cluster headaches. Studies typically show significant headache relief and reduction in associated symptoms compared to placebo.
Lab Monitoring
- No specific routine lab monitoring is required. Patients with risk factors for cardiovascular disease should undergo a cardiovascular evaluation before starting sumatriptan and periodically thereafter.
Doctor Notes
- Counsel patients on proper use and warning signs.
- Assess cardiovascular risk factors before prescribing.
- Limit use to 2 doses in 24 hours for acute attacks.
- Advise against prophylactic use.
Patient Guidelines
- Take as soon as migraine symptoms appear.
- Do not take more than the prescribed dose.
- If migraine is not relieved, do not take a second dose for the same attack; consult your doctor.
- Avoid using if you have heart problems or uncontrolled high blood pressure.
Missed Dose Advice
This medicine is taken as needed for migraine attacks, not on a regular schedule. Therefore, a missed dose typically does not apply. Take a dose when a migraine attack begins.
Driving Precautions
Sumatriptan can cause dizziness, drowsiness, or blurred vision. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Identify and avoid migraine triggers (e.g., certain foods, stress, lack of sleep).
- Maintain a regular sleep schedule.
- Stay hydrated and eat regular meals.
- Manage stress through relaxation techniques.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Imigra Brand
Other medicines available under the same brand name
