Infanil
Generic Name
Ibuprofen
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| infanil 250 mg tablet | ৳ 25.08 | N/A |
Description
Overview of the medicine
Infanil 250 mg Tablet contains Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly used for conditions like headaches, menstrual cramps, arthritis, and muscular pain.
Uses & Indications
Dosage
Adults
200-400 mg every 4-6 hours as needed. Max 1200 mg/day (for OTC use) or up to 3200 mg/day (under medical supervision for specific conditions). For 250mg, typically 250mg 3-4 times daily.
Elderly
Use lowest effective dose, monitor for adverse effects, especially renal.
Renal_impairment
Reduce dose and monitor renal function; avoid in severe impairment.
How to Take
Take orally with food, milk, or an antacid to minimize gastrointestinal upset. Swallow whole with a glass of water.
Mechanism of Action
Ibuprofen works by inhibiting the activity of cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are compounds that cause pain, fever, and inflammation. By reducing prostaglandin production, Ibuprofen helps alleviate these symptoms.
Pharmacokinetics
Onset
Pain relief within 30 minutes, anti-inflammatory effects may take longer.
Excretion
Primarily excreted in the urine as metabolites and their conjugates, with a small amount excreted unchanged.
Half life
Approximately 1.8 to 2.5 hours.
Absorption
Rapidly absorbed from the GI tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by oxidation and conjugation.
Side Effects
Contraindications
- Hypersensitivity to Ibuprofen or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, drowsiness, dizziness, nystagmus, apnea, and coma. Management involves symptomatic and supportive care, gastric lavage or activated charcoal if recent ingestion, and correction of fluid/electrolyte imbalances.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use in first and second trimesters only if clearly needed and benefits outweigh risks. Small amounts may pass into breast milk; generally considered compatible with breastfeeding with caution.
Side Effects
Contraindications
- Hypersensitivity to Ibuprofen or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure, renal failure, or hepatic failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, drowsiness, dizziness, nystagmus, apnea, and coma. Management involves symptomatic and supportive care, gastric lavage or activated charcoal if recent ingestion, and correction of fluid/electrolyte imbalances.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use in first and second trimesters only if clearly needed and benefits outweigh risks. Small amounts may pass into breast milk; generally considered compatible with breastfeeding with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, hospitals, supermarkets
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for pain, fever, and inflammatory conditions. Post-marketing surveillance continues to monitor long-term safety.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (creatinine, BUN)
- Liver function tests (ALT, AST)
Doctor Notes
- Advise patients to report any black, tarry stools or severe stomach pain immediately.
- Caution in patients with a history of asthma or allergies, as NSAIDs can precipitate bronchospasm.
- Monitor blood pressure in hypertensive patients, as NSAIDs can elevate it.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not exceed recommended dose.
- Avoid alcohol while taking this medicine.
- Report any signs of unusual bleeding or stomach pain.
- Consult your doctor if pain persists for more than 10 days or fever for more than 3 days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
May cause dizziness or drowsiness; if affected, avoid driving or operating machinery.
Lifestyle Advice
- Stay hydrated.
- Avoid strenuous activities if pain is severe.
- Apply hot/cold packs for localized pain.
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International brand names for this medicine. Click a brand to search for detailed information.
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