Intracef
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| intracef 125 mg pediatric drop | ৳ 50.00 | N/A |
Description
Overview of the medicine
Cefixime is a third-generation cephalosporin antibiotic used to treat various bacterial infections in children. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not applicable for this pediatric formulation; adult dosage forms are different.
Elderly
Not applicable for this pediatric formulation; elderly dosage forms are different.
Renal_impairment
For children with creatinine clearance less than 60 mL/min, dosage adjustment is required. Consult a physician.
How to Take
Administer orally with or without food. Use a measuring spoon or dropper provided for accurate dosing. Shake the suspension well before each use.
Mechanism of Action
Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding prevents the cross-linking of peptidoglycan units, which are essential for the integrity and rigidity of the bacterial cell wall, leading to cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentration reached in 2-6 hours.
Excretion
Primarily excreted unchanged in the urine (about 50%) via glomerular filtration and tubular secretion. Some excretion in bile/faeces.
Half life
About 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not affect the extent.
Metabolism
Not extensively metabolized; about 10% appears to be metabolized.
Side Effects
Contraindications
- •Known hypersensitivity to cefixime, other cephalosporins, or any component of the formulation.
- •History of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis).
Drug Interactions
Warfarin
Increased prothrombin time (PT) and INR, leading to increased bleeding risk.
Carbamazepine
Increased plasma carbamazepine levels.
Oral Contraceptives
Reduced efficacy of oral contraceptives.
Storage
Store dry powder at controlled room temperature, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after 7-14 days (check specific product label). Do not freeze.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for dry powder. Once reconstituted, typically 7-14 days when stored as directed (refer to product leaflet).
Availability
Pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
