Kacin
Generic Name
Amikacin Sulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kacin 500 mg injection | ৳ 60.00 | N/A |
Description
Overview of the medicine
Kacin 500 mg Injection contains Amikacin, an aminoglycoside antibiotic used to treat a wide range of severe bacterial infections, particularly those caused by Gram-negative bacteria that are resistant to other antibiotics. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
15 mg/kg/day, administered as 7.5 mg/kg every 12 hours or 5 mg/kg every 8 hours, for 7 to 10 days. Maximum dose: 1.5 g/day.
Elderly
Dosage should be adjusted based on renal function (creatinine clearance). Lower doses or extended dosing intervals may be necessary.
Renal_impairment
Significant dose adjustment required. Dosage interval or dose size should be modified based on creatinine clearance and monitored serum drug levels. Initial dose is usually 7.5 mg/kg.
How to Take
Kacin 500 mg Injection can be administered by deep intramuscular (IM) injection or by intravenous (IV) infusion over 30 to 60 minutes. For IV infusion, the drug should be diluted in a suitable sterile diluent (e.g., 0.9% Sodium Chloride Injection, 5% Dextrose Injection).
Mechanism of Action
Amikacin binds to the 30S ribosomal subunit of susceptible bacteria, inhibiting bacterial protein synthesis and leading to cell death. It exhibits concentration-dependent bactericidal activity.
Pharmacokinetics
Onset
Rapid onset of action, typically within minutes of IV administration and 30 minutes to 1 hour after IM administration.
Excretion
Excreted almost entirely via glomerular filtration in the urine as unchanged drug.
Half life
Approximately 2-3 hours in adults with normal renal function.
Absorption
Rapid and complete absorption after intramuscular (IM) administration; immediate after intravenous (IV) administration.
Metabolism
Not significantly metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to amikacin or other aminoglycosides
- •Myasthenia gravis
- •Parkinsonism
Drug Interactions
Other Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity.
Penicillins/Cephalosporins
In vitro inactivation (do not mix in the same syringe); however, in vivo, they can have synergistic effects against certain bacteria.
Ototoxic drugs (e.g., Furosemide, Ethacrynic acid)
Increased risk of ototoxicity.
Neuromuscular blockers (e.g., Succinylcholine, Vecuronium)
Enhanced neuromuscular blockade, potentially leading to respiratory depression/paralysis.
Nephrotoxic drugs (e.g., Amphotericin B, Ciclosporin, Cisplatin, Vancomycin, NSAIDs)
Increased risk of nephrotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose can lead to severe nephrotoxicity, ototoxicity, and neuromuscular blockade. Management includes discontinuing the drug, supportive care, and ensuring adequate hydration. Hemodialysis or peritoneal dialysis can aid in the removal of amikacin from the blood.
Pregnancy & Lactation
Pregnancy Category D. Amikacin can cause fetal harm, including congenital deafness. Use only if potential benefit justifies potential fetal risk. It is excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother. Monitor the infant for diarrhea, candidiasis, and hearing loss.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check manufacturer's label for exact date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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