Klavin
Generic Name
Amoxicillin + Clavulanic Acid
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| klavin 500 mg tablet | ৳ 40.00 | N/A |
| klavin 125 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Klavin is an antibiotic containing Amoxicillin and Clavulanic Acid. It is used to treat a wide range of bacterial infections that are resistant to Amoxicillin alone due to beta-lactamase producing bacteria.
Uses & Indications
Dosage
Adults
Usual adult dose is 500 mg amoxicillin/125 mg clavulanic acid three times a day, or 875 mg amoxicillin/125 mg clavulanic acid twice a day, depending on the severity and type of infection.
Elderly
Dosage as for adults, but renal function should be monitored, and dose adjusted if necessary.
Renal_impairment
Dosage should be adjusted based on creatinine clearance (e.g., lower dose or extended dosing interval for severe impairment).
How to Take
Take at the start of a meal to minimize potential gastrointestinal intolerance and enhance absorption. Complete the full course of treatment as prescribed by your doctor.
Mechanism of Action
Amoxicillin works by inhibiting bacterial cell wall synthesis, leading to cell lysis. Clavulanic Acid inhibits beta-lactamase enzymes produced by bacteria, thereby preventing the breakdown of amoxicillin and extending its antibacterial spectrum.
Pharmacokinetics
Onset
Rapid; peak plasma levels usually within 1-2 hours.
Excretion
Primarily via the kidneys; amoxicillin is excreted largely unchanged, while clavulanic acid is excreted as metabolites and unchanged drug.
Half life
Amoxicillin: Approximately 1-1.5 hours; Clavulanic Acid: Approximately 1 hour.
Absorption
Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved approximately 1-2 hours after dosing.
Metabolism
Amoxicillin is minimally metabolized; clavulanic acid is extensively metabolized to inactive compounds.
Side Effects
Contraindications
- History of hypersensitivity to penicillins or any other beta-lactam antibiotics (e.g., cephalosporins)
- History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid therapy
Drug Interactions
Warfarin
Increased INR/prothrombin time, requiring careful monitoring.
Allopurinol
Increased incidence of skin rash when co-administered.
Methotrexate
Reduced renal tubular secretion of methotrexate, potentially increasing its toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include gastrointestinal symptoms and disturbances in fluid and electrolyte balance. Management is symptomatic and supportive, with hemodialysis if severe.
Pregnancy & Lactation
Pregnancy category B. Use with caution during pregnancy; consult a doctor. Excreted in breast milk in small amounts; generally considered safe during lactation, but monitor for adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensively studied since its introduction, with numerous clinical trials supporting its efficacy and safety in various bacterial infections.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment or prolonged therapy)
- Renal function tests
Doctor Notes
- Consider culture and susceptibility tests prior to initiating treatment to guide therapy.
- Caution in patients with hepatic and/or renal impairment. Monitor liver function tests periodically during prolonged therapy.
Patient Guidelines
- Take the full course of treatment as prescribed, even if you feel better.
- Take with food to reduce stomach upset.
- Do not share your medication with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals. If affected, avoid driving or operating machinery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.