Kofen
Generic Name
Ketorolac Tromethamine Ophthalmic Solution 0.25%
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kofen 0025 eye drop | ৳ 100.30 | N/A |
Description
Overview of the medicine
Kofen 0.25% Eye Drop is an ophthalmic solution containing Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID). It is used to relieve eye pain and inflammation following cataract surgery and to treat seasonal allergic conjunctivitis symptoms.
Uses & Indications
Dosage
Adults
1 drop in the affected eye(s) four times a day.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No specific dosage adjustment required for renal impairment due to minimal systemic absorption.
How to Take
For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch, instill one drop, then gently close eye. Do not touch the dropper tip to any surface to avoid contamination. If using other eye drops, wait at least 5 minutes between applications.
Mechanism of Action
Ketorolac Tromethamine inhibits the cyclooxygenase (COX-1 and COX-2) enzymes, thereby blocking the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. In the eye, this reduces ocular inflammation and pain.
Pharmacokinetics
Onset
Pain relief within 1 hour.
Excretion
Primarily renal (kidney) excretion if absorbed systemically.
Half life
Approximately 3.5-6 hours in systemic circulation, but less relevant for ophthalmic use due to minimal systemic absorption.
Absorption
Minimal systemic absorption after ocular administration. Plasma concentrations are typically undetectable or very low.
Metabolism
Primarily hepatic (liver) metabolism if absorbed systemically.
Side Effects
Contraindications
- •Hypersensitivity to ketorolac tromethamine or any component of the formulation
- •Patients with a history of aspirin or other NSAID-induced bronchospasm, allergic rhinitis, or urticaria
Drug Interactions
Other topical NSAIDs
Concurrent use may increase the risk of adverse effects.
Anticoagulants (e.g., Warfarin)
Although systemic absorption is minimal, theoretical risk of increased bleeding tendency with high doses or prolonged use.
Storage
Store at room temperature (below 30°C), protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with ophthalmic ketorolac is unlikely due to the small volume of the solution and minimal systemic absorption. If accidentally ingested, symptomatic and supportive treatment may be provided.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, but check expiry date on packaging. Discard 28 days after opening.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
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