kofen
Generic Name
ketotifen
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kofen 1 mg syrup | ৳ 55.00 | N/A |
Description
Overview of the medicine
Kofen 1 mg Syrup contains Ketotifen, an antihistamine and mast cell stabilizer, primarily used for the long-term prophylactic treatment of bronchial asthma, allergic conjunctivitis, and other allergic conditions.
Uses & Indications
Dosage
Adults
1 mg (5 ml) twice daily with food. If necessary, the dose may be increased to 2 mg (10 ml) twice daily.
Elderly
No specific dosage adjustment is generally required, but caution is advised due to potential for increased sensitivity.
Renal_impairment
No specific dosage adjustment mentioned for mild to moderate impairment; use with caution in severe impairment.
How to Take
Administer orally, usually with food, to minimize gastrointestinal upset. Consistent administration is important for prophylactic effect.
Mechanism of Action
Ketotifen inhibits the release of histamine and other mediators from mast cells and blocks H1-histamine receptors. It also antagonizes the effects of leukotrienes, thereby reducing allergic inflammation.
Pharmacokinetics
Onset
Antihistaminic effect within hours; prophylactic anti-asthmatic effect may take several weeks (2-3 months) to develop fully.
Excretion
Excreted mainly in urine (about 60-70%) as metabolites, with a small amount excreted unchanged.
Half life
Plasma half-life of 12-24 hours for the parent compound, with an active metabolite having a longer half-life.
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 50% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by N-glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to Ketotifen or any component of the formulation
- •Acute asthma attacks (not for rescue therapy)
Drug Interactions
Alcohol
May enhance the CNS depressant effects.
Oral Antidiabetics
Reports of reversible decrease in platelet count (though rare, monitor).
Other Antihistamines
Additive sedative effects.
CNS Depressants (e.g., Sedatives, Hypnotics)
Increased sedative effects.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms include drowsiness, confusion, disorientation, tachycardia, and potentially convulsions. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; avoid during lactation or consider alternatives.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when unopened.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
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Global Brand Names
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