Kuit
Generic Name
Ketotifen Fumarate
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kuit 2 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Kuit 2 mg Tablet contains Ketotifen Fumarate, which is an antihistamine and mast cell stabilizer. It is primarily used for the prophylactic treatment of bronchial asthma, allergic bronchitis, allergic rhinitis, and other allergic conditions.
Uses & Indications
Dosage
Adults
1 mg (half tablet of 2 mg) twice daily with food. If necessary, the dose may be increased to 2 mg (one tablet) twice daily.
Elderly
No specific dose adjustment is usually required for elderly patients, but caution is advised in those with impaired renal or hepatic function.
Renal_impairment
Use with caution. Dose adjustment may be necessary in severe renal impairment due to potential accumulation of metabolites.
How to Take
Kuit tablets should be taken orally with food to minimize gastrointestinal discomfort.
Mechanism of Action
Ketotifen inhibits the release of histamine and other inflammatory mediators from mast cells and also acts as an H1-receptor antagonist, thereby reducing allergic reactions and inflammation.
Pharmacokinetics
Onset
Antihistaminic effects may appear within hours, but prophylactic effect in asthma can take several weeks (2-12 weeks) to become fully established.
Excretion
Approximately 60-70% of the dose is excreted renally, mainly as metabolites, within 48 hours. A minor portion is excreted via feces.
Half life
Biphasic elimination with a short initial half-life (3-5 hours) and a longer terminal half-life (12-24 hours).
Absorption
Well absorbed orally (approximately 70-75%), but undergoes significant first-pass metabolism. Absolute bioavailability is about 50%. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by N-glucuronidation. The main metabolite is ketotifen-N-glucuronide, which is inactive.
Side Effects
Contraindications
- •Hypersensitivity to Ketotifen or any component of the formulation.
- •Patients with a history of epilepsy or seizure disorders (use with caution as it may lower seizure threshold).
- •Breastfeeding mothers.
Drug Interactions
Bronchodilators
May allow for a reduction in the dosage of bronchodilators, but careful monitoring is required.
CNS Depressants
May potentiate the effects of CNS depressants such as alcohol, hypnotics, sedatives, and other antihistamines, leading to increased drowsiness.
Oral Antidiabetics
There have been rare reports of reversible thrombocytopenia in patients concurrently using ketotifen and oral antidiabetic agents; therefore, concurrent use should be avoided.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, disorientation, tachycardia, hypotension, and rarely seizures, especially in children. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if recent ingestion. Monitoring vital signs is crucial.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is contraindicated in breastfeeding mothers as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA/FDA
Patent Status
Expired
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