Labegest
Generic Name
Labetalol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| labegest 100 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Labegest 100 mg Tablet contains Labetalol, an alpha and beta-adrenergic blocking agent used to treat high blood pressure (hypertension). It works by relaxing blood vessels and slowing the heart rate, making it easier for the heart to pump blood.
Uses & Indications
Dosage
Adults
Initially 100 mg twice daily, may be increased in increments of 100 mg twice daily every 2-3 days until desired blood pressure response is achieved. Usual maintenance dose is 200-400 mg twice daily. Max dose: 2400 mg/day.
Elderly
Lower initial doses (e.g., 50 mg twice daily) may be appropriate, with gradual titration based on response and tolerability.
Renal_impairment
No specific dose adjustment is usually necessary for patients with renal impairment, but caution is advised in severe cases.
How to Take
Take orally, with or without food. To minimize orthostatic effects, it is generally recommended to take with food.
Mechanism of Action
Labetalol is a non-selective beta-adrenergic blocker and a selective alpha1-adrenergic blocker. It blocks beta1 and beta2 receptors, causing a decrease in heart rate and myocardial contractility, and blocks alpha1 receptors, leading to vasodilation and reduced peripheral vascular resistance. The combined effect lowers blood pressure.
Pharmacokinetics
Onset
Oral: 20 minutes to 2 hours; IV: 2-5 minutes.
Excretion
Primarily excreted in urine (approximately 55-60%) and feces (approximately 30%).
Half life
Oral: 6-8 hours; IV: 5-5.5 hours.
Absorption
Well absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily via conjugation and glucuronidation.
Side Effects
Contraindications
- Bronchial asthma or chronic obstructive pulmonary disease (COPD)
- Decompensated heart failure
- Second or third-degree atrioventricular (AV) block
- Severe bradycardia
- Cardiogenic shock
- Hypersensitivity to Labetalol
Drug Interactions
Cimetidine
Increases Labetalol bioavailability.
Tricyclic Antidepressants (TCAs)
May increase the risk of tremor.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
May reduce the antihypertensive effects of Labetalol.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension, bradycardia, bronchospasm, and heart failure. Treatment involves symptomatic and supportive measures. Atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C (old system); however, it is commonly used for hypertension in pregnancy due to its relatively good safety profile. Labetalol is excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Bronchial asthma or chronic obstructive pulmonary disease (COPD)
- Decompensated heart failure
- Second or third-degree atrioventricular (AV) block
- Severe bradycardia
- Cardiogenic shock
- Hypersensitivity to Labetalol
Drug Interactions
Cimetidine
Increases Labetalol bioavailability.
Tricyclic Antidepressants (TCAs)
May increase the risk of tremor.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
May reduce the antihypertensive effects of Labetalol.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension, bradycardia, bronchospasm, and heart failure. Treatment involves symptomatic and supportive measures. Atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C (old system); however, it is commonly used for hypertension in pregnancy due to its relatively good safety profile. Labetalol is excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of labetalol in managing hypertension, including studies on its use in pregnancy and hypertensive emergencies.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Liver function tests (periodically)
Doctor Notes
- Advise patients to monitor their blood pressure regularly.
- Emphasize the importance of not discontinuing the drug suddenly.
- Be aware of potential drug interactions, especially with other antihypertensives or heart medications.
Patient Guidelines
- Take medicine regularly as prescribed by your doctor.
- Do not stop taking this medicine abruptly without consulting your doctor.
- Report any unusual side effects to your doctor.
- Avoid sudden changes in position to prevent dizziness.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Maintain a healthy weight.
- Limit alcohol consumption.
- Quit smoking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Labegest Brand
Other medicines available under the same brand name
