Labegest
Generic Name
Labetalol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| labegest 200 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Labegest 200 mg Tablet contains Labetalol, which is a combined alpha- and beta-adrenoceptor blocking agent used to treat hypertension and angina pectoris. It helps to lower blood pressure and reduce the heart's workload.
Uses & Indications
Dosage
Adults
Initial dose 100 mg twice daily, increasing to 200 mg twice daily after 2-3 days. Maintenance dose 200-400 mg twice daily, up to a maximum of 2.4 g daily in divided doses.
Elderly
Lower initial doses and slower titration may be appropriate, e.g., 50 mg twice daily.
Renal_impairment
No specific dosage adjustment required, but caution is advised in severe renal impairment.
How to Take
Take orally, with or without food. Consistent timing relative to meals is recommended for optimal absorption.
Mechanism of Action
Labetalol acts as a non-selective beta-adrenergic and selective alpha-1 adrenergic receptor blocker. It reduces peripheral vascular resistance by blocking alpha-1 receptors, and decreases heart rate and cardiac output by blocking beta-receptors. The combined effect leads to a reduction in blood pressure without reflex tachycardia.
Pharmacokinetics
Onset
Oral: 20-120 minutes
Excretion
Mainly excreted in urine as metabolites and, to a lesser extent, as unchanged drug. Some excretion via bile.
Half life
Approximately 6-8 hours
Absorption
Well absorbed from the GI tract (approximately 100%), but undergoes significant first-pass metabolism, resulting in approximately 25% bioavailability.
Metabolism
Extensively metabolized in the liver, primarily via conjugation with glucuronic acid.
Side Effects
Contraindications
- Bronchial asthma or history of obstructive airway disease
- Heart block greater than first degree (unless paced)
- Cardiogenic shock
- Severe bradycardia
- Decompensated heart failure
- Hypotension
Drug Interactions
Cimetidine
Increases Labetalol bioavailability.
Nitroglycerin
Increased hypotensive effect.
Beta-2 agonists
May reduce bronchodilator effect.
Tricyclic antidepressants
Increased risk of tremor.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypotension, bradycardia, bronchospasm, and acute heart failure. Treatment involves symptomatic and supportive measures, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm. Hemodialysis is largely ineffective.
Pregnancy & Lactation
Pregnancy Category C/D (depending on trimester). Considered relatively safe for managing hypertension in pregnancy, especially pre-eclampsia. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for bradycardia or lethargy.
Side Effects
Contraindications
- Bronchial asthma or history of obstructive airway disease
- Heart block greater than first degree (unless paced)
- Cardiogenic shock
- Severe bradycardia
- Decompensated heart failure
- Hypotension
Drug Interactions
Cimetidine
Increases Labetalol bioavailability.
Nitroglycerin
Increased hypotensive effect.
Beta-2 agonists
May reduce bronchodilator effect.
Tricyclic antidepressants
Increased risk of tremor.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypotension, bradycardia, bronchospasm, and acute heart failure. Treatment involves symptomatic and supportive measures, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm. Hemodialysis is largely ineffective.
Pregnancy & Lactation
Pregnancy Category C/D (depending on trimester). Considered relatively safe for managing hypertension in pregnancy, especially pre-eclampsia. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for bradycardia or lethargy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Labetalol has been extensively studied in various clinical trials for hypertension, including its efficacy in pregnancy-induced hypertension and hypertensive emergencies. Studies demonstrate its dual alpha-beta blocking properties and safety profile.
Lab Monitoring
- Blood pressure
- Heart rate
- Liver function tests (periodically)
- Renal function tests (periodically)
Doctor Notes
- Educate patients on potential orthostatic hypotension.
- Advise against abrupt discontinuation.
- Monitor BP and heart rate carefully, especially during dose titration.
- Consider use in pregnant hypertensive patients, carefully weighing benefits and risks.
Patient Guidelines
- Take medicine regularly as prescribed by your doctor.
- Do not stop taking this medicine abruptly without consulting your doctor.
- Monitor your blood pressure regularly.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose to make up for a missed one.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment or after dose increase. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
- Manage stress effectively.
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International brand names for this medicine. Click a brand to search for detailed information.
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