Lasgrain
Generic Name
Pizotifen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lasgrain 50 mg tablet | ৳ 40.00 | ৳ 400.00 |
| lasgrain 100 mg tablet | ৳ 75.00 | ৳ 300.00 |
Description
Overview of the medicine
Lasgrain (Pizotifen) is a serotonin and histamine antagonist primarily used for the prophylactic treatment of various types of vascular headaches, including migraine and cluster headaches. It may also stimulate appetite.
Uses & Indications
Dosage
Adults
Initial dose 0.5 mg at night, gradually increased to 0.5 mg three times daily or 1.5 mg once daily at night. Max 3 mg/day.
Elderly
Same as adults, but caution advised due to increased sensitivity to anticholinergic effects.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment. Use with caution.
How to Take
Oral administration. Can be taken with or without food. To minimize sedation, initial doses should be taken at night.
Mechanism of Action
Pizotifen acts as a serotonin (5-HT1 and 5-HT2) antagonist and a weak H1-receptor antagonist. It is believed to stabilize cranial blood vessels and reduce the inflammatory response associated with migraine. It also has appetite stimulant properties.
Pharmacokinetics
Onset
Not specified, but prophylactic effects take several weeks.
Excretion
Primarily excreted in urine (mainly as metabolites).
Half life
Approximately 20-25 hours.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver (N-glucuronidation).
Side Effects
Contraindications
- •Hypersensitivity to Pizotifen or any excipients
- •Acute angle-closure glaucoma
- •Urinary retention
Drug Interactions
Anticholinergic drugs
Increased anticholinergic effects (e.g., dry mouth, constipation, urinary retention).
CNS depressants (alcohol, sedatives, hypnotics)
Increased sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, coma, ataxia, tachycardia, hypotension, nausea, vomiting, confusion, and hallucinations. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid during lactation as Pizotifen is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available, original patent expired
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Global Brand Names
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