Adults

For bacterial conjunctivitis: Instill 1-2 drops into the affected eye(s) every 2 hours while awake, up to 8 times per day, for the first 2 days, then 1-2 drops every 4 hours while awake, up to 4 times per day, from day 3 through day 7. For bacterial keratitis: Instill 1 drop into the affected eye(s) every 30 minutes to 1 hour while awake for the first 1-2 days, then every 1-2 hours while awake for 3-5 days, then reduce frequency as directed by physician.

Elderly

No dosage adjustment is typically required for elderly patients.

Renal_impairment

No dosage adjustment is necessary for topical ophthalmic use in patients with renal impairment due to minimal systemic absorption.

Onset

Clinical improvement typically observed within 2-5 days of initiation of treatment.

Excretion

Mainly eliminated via tears and minimal systemic renal excretion for the small absorbed fraction.

Half life

Systemic half-life is approximately 6-8 hours, but for topical ophthalmic use, local half-life in ocular tissues is more relevant, with sustained therapeutic concentrations.

Absorption

Following topical ocular administration, levofloxacin is absorbed into the ocular tissues (cornea, aqueous humor, iris, ciliary body) with minimal systemic absorption. Peak concentrations in tears are rapidly achieved.

Metabolism

Minimal systemic metabolism. Primarily unmetabolized.

Other topical ocular medications

If using other topical ophthalmic medications, wait at least 5 minutes between applying each medication to allow for proper absorption and avoid washout.