Libott
Generic Name
Fictional Coxamide
Manufacturer
Fictional Pharma Inc.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| libott 10 injection | ৳ 78.20 | N/A |
Description
Overview of the medicine
Libott-10 Injection contains Fictional Coxamide, a selective COX-2 inhibitor, used for the rapid relief of acute pain and inflammation, particularly in cases where oral administration is not feasible.
Uses & Indications
Dosage
Adults
10 mg (1 mL) intramuscularly or intravenously every 12-24 hours as needed, not exceeding 20 mg in 24 hours. Max treatment duration: 5 days for acute pain.
Elderly
Lower doses may be required; careful monitoring for adverse effects. Max 10 mg/day.
Renal_impairment
Initial dose 5 mg (0.5 mL) every 24 hours. Avoid in severe renal impairment (CrCl <30 mL/min).
How to Take
For intramuscular (IM) or slow intravenous (IV) injection. IV administration should be diluted and given over 15-30 minutes.
Mechanism of Action
Fictional Coxamide selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. By inhibiting COX-2, it reduces prostaglandin production, leading to anti-inflammatory, analgesic, and antipyretic effects with reduced gastrointestinal side effects compared to non-selective NSAIDs.
Pharmacokinetics
Onset
15-30 minutes (analgesia)
Excretion
Mainly excreted in urine (approx. 60%) and feces (approx. 40%) as metabolites.
Half life
Approximately 6-8 hours
Absorption
Rapidly absorbed after intramuscular or intravenous administration. Peak plasma concentrations are achieved within 30 minutes to 1 hour.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes (e.g., CYP2C9), forming inactive metabolites.
Side Effects
Contraindications
- •Known hypersensitivity to Fictional Coxamide or other NSAIDs
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Active peptic ulcer, gastrointestinal bleeding, or perforation
- •Severe heart failure, severe renal impairment, or severe hepatic impairment
- •Third trimester of pregnancy
- •Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if recent oral ingestion. No specific antidote.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus and renal dysfunction in the fetus. Use during early pregnancy and lactation only if clearly needed and benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in hospitals, clinics, and pharmacies nationwide.
Approval Status
Approved by regulatory authorities in several countries including Bangladesh.
Patent Status
Patented by the manufacturer
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
