Libott
Generic Name
Libottine 5 mg Injection
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| libott 5 injection | ৳ 71.31 | N/A |
Description
Overview of the medicine
Libott-5 Injection is an anxiolytic medicine used for rapid relief of acute anxiety, agitation, and for short-term management of insomnia or pre-operative sedation.
Uses & Indications
Dosage
Adults
Acute anxiety/agitation: 5-10 mg IM or slow IV, may be repeated every 4-6 hours if needed. Max 20 mg/day. Pre-operative: 2.5-5 mg IM 30-60 minutes before surgery.
Elderly
2.5-5 mg IM or slow IV, dose should be carefully titrated due to increased sensitivity and risk of side effects.
Renal_impairment
Dose adjustment may be necessary; use with caution. No specific guidelines, often start with lower doses.
How to Take
Administer intramuscularly (IM) deep into a large muscle mass, or slowly intravenously (IV) into a large vein.
Mechanism of Action
It works by enhancing the effect of a natural chemical in the body (GABA), which calms the brain and nerves, inducing a feeling of relaxation and sedation.
Pharmacokinetics
Onset
5-15 minutes after IV administration; 15-30 minutes after IM administration.
Excretion
Mainly excreted in urine as inactive metabolites.
Half life
6-10 hours.
Absorption
Rapidly absorbed following intramuscular (IM) or intravenous (IV) administration.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to Libottine or any component of the formulation
- •Acute narrow-angle glaucoma
- •Severe respiratory insufficiency
- •Myasthenia gravis
- •Sleep apnea
Drug Interactions
Alcohol
Enhances CNS depressant effects; avoid concomitant use.
Opioids
Significant risk of respiratory depression, sedation, coma, and death. Strict monitoring and dose reduction required.
Central Nervous System (CNS) Depressants
Increased risk of sedation, respiratory depression, hypotension, and profound CNS depression. Avoid coadministration.
CYP450 Inhibitors (e.g., ketoconazole, fluoxetine)
May increase Libottine plasma levels, leading to enhanced effects and side effects. Dose adjustment may be necessary.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, diminished reflexes, coma, and cardiorespiratory depression. Management is supportive: maintain airway, assist ventilation, monitor vital signs. Flumazenil may be used to reverse benzodiazepine effects, but use with caution due to risk of seizures.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. Excreted in breast milk; avoid use during lactation or monitor infant for sedation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in hospitals and pharmacies
Approval Status
Approved by DGDA
Patent Status
Off-patent
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Global Brand Names
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