Medicine Information

Linbid

Name: Linbid
Brand: Linbid
Rating: 4.5 (117 reviews)

Tablet400 mgQuinolone AntibioticsATC: J01MA12

Generic Name

Levofloxacin

Manufacturer

Hypothetical Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
linbid 400 mg tablet	৳ 55.00	৳ 550.00

Description

Overview of the medicine

Linbid 400 mg Tablet contains Levofloxacin, a fluoroquinolone antibiotic used to treat a variety of bacterial infections.

Uses & Indications

Acute bacterial sinusitis

Acute exacerbation of chronic bronchitis

Community-acquired pneumonia

Complicated skin and skin structure infections

Complicated urinary tract infections and pyelonephritis

Prostatitis

Dosage

Adults

Typical dosage is 400 mg once daily for 7-14 days, depending on the type and severity of infection. For example, 400 mg once daily for 10-14 days for community-acquired pneumonia.

Elderly

No specific dose adjustment based on age alone; however, renal function should be assessed, and dosage adjusted accordingly if impaired.

Renal_impairment

Dosage adjustment is necessary for patients with creatinine clearance less than 50 mL/min. For CrCl 20-49 mL/min: Initial dose 400 mg, then 200 mg every 24 hours. For CrCl 10-19 mL/min: Initial dose 400 mg, then 100 mg every 24 hours.

How to Take

Take orally, with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.

Mechanism of Action

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.

Pharmacokinetics

Onset

Within 1-2 hours (for significant plasma levels, clinical effects vary based on infection type and site).

Excretion

Primarily excreted unchanged by the kidneys, with approximately 87% of an oral dose recovered in the urine within 48 hours.

Half life

Approximately 6-8 hours, increasing with renal impairment.

Absorption

Rapid and almost complete absorption after oral administration; bioavailability approximately 99%. Peak plasma concentrations are usually achieved within 1-2 hours.

Metabolism

Minimally metabolized in the liver to inactive metabolites. About 5% of a dose is metabolized.

Side Effects

Contraindications

Hypersensitivity to levofloxacin or other fluoroquinolones.
History of tendinitis or tendon rupture associated with fluoroquinolone use.
Epilepsy.
Children or adolescents (under 18 years of age).
Pregnancy and breastfeeding.

Drug Interactions

NSAIDs

May increase the risk of CNS stimulation and convulsive seizures when co-administered with fluoroquinolones.

Warfarin

May enhance the anticoagulant effects of warfarin, requiring close monitoring of INR.

Corticosteroids

Increased risk of tendinitis and tendon rupture when co-administered with fluoroquinolones.

Diabetes medications (e.g., Insulin, oral hypoglycemics)

May cause dysglycemia (hypoglycemia or hyperglycemia), requiring careful blood glucose monitoring.

Antacids containing magnesium or aluminum, Sucralfate, Metal cations (iron, zinc)

Can significantly reduce absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

In the event of an acute overdose, the stomach should be emptied. The patient should be observed and given supportive treatment. Hydration should be maintained. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and should be avoided during breastfeeding due to potential risk of arthropathy in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

7 tablets (1x7 strip)10 tablets (1x10 strip)30 tablets (3x10 strip)

Shelf Life

2-3 years from the date of manufacture, typically indicated on the packaging.

Availability

Available in pharmacies worldwide, including Bangladesh

Approval Status

Approved by FDA and DGDA (Bangladesh)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have been conducted to establish the efficacy and safety of Levofloxacin for its approved indications, demonstrating its broad-spectrum antibacterial activity and favorable pharmacokinetic profile.

Lab Monitoring

Renal function tests (creatinine clearance) in patients with impaired kidney function.
Blood glucose monitoring in diabetic patients due to risk of dysglycemia.
INR monitoring in patients receiving warfarin.

Doctor Notes

Assess renal function before prescribing, especially in elderly patients, and adjust dose accordingly.
Counsel patients about the risk of tendinitis/tendon rupture and peripheral neuropathy; advise immediate discontinuation and seeking medical attention if symptoms occur.
Avoid concomitant use with multivalent cations (antacids, iron, zinc) or space administration appropriately.
Monitor blood glucose closely in diabetic patients due to risk of dysglycemia.
Contraindicated in patients with a history of myasthenia gravis due to exacerbation risk.

Patient Guidelines

Complete the entire prescribed course of Linbid, even if you feel better.
Avoid excessive exposure to sunlight or artificial UV light, and use sunscreen and protective clothing.
Report any pain, swelling, or inflammation in a tendon, or numbness/tingling, to your doctor immediately.
Do not take antacids or iron supplements within 2 hours of taking Linbid.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause dizziness, lightheadedness, or visual disturbances. Exercise caution or avoid driving and operating machinery until you know how Linbid affects you.

Lifestyle Advice

Maintain adequate hydration during treatment.
Avoid smoking and excessive alcohol consumption as they may exacerbate certain side effects or overall health issues.