Linlid
Generic Name
Linezolid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| linlid 100 mg suspension | ৳ 280.00 | N/A |
Description
Overview of the medicine
Linezolid is an antibiotic used to treat serious bacterial infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE).
Uses & Indications
Dosage
Adults
600 mg intravenously or orally every 12 hours for 10 to 14 consecutive days.
Elderly
No dose adjustment is required.
Renal_impairment
No dose adjustment needed for mild to severe renal impairment. Consider the timing of doses in relation to hemodialysis sessions.
How to Take
Shake the bottle well before each use. Administer orally with or without food. Use the provided measuring cup or syringe for accurate dosing.
Mechanism of Action
Linezolid inhibits bacterial protein synthesis by binding to the 23S rRNA of the 50S ribosomal subunit, preventing the formation of the 70S initiation complex.
Pharmacokinetics
Onset
Clinical effects typically observed within 2-4 days of initiation of therapy.
Excretion
Approximately 65% of the dose is excreted via renal and non-renal pathways as metabolites, and 30% as unchanged drug in urine.
Half life
Approximately 4-5 hours.
Absorption
Rapid and extensive absorption from the gastrointestinal tract, with absolute bioavailability of approximately 100%. Peak plasma concentrations occur within 1-2 hours.
Metabolism
Primarily by oxidation of the morpholine ring, resulting in two inactive carboxylic acid metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Linezolid or any component of the formulation.
- •Concurrent use of MAO inhibitors (e.g., phenelzine, isocarboxazid, tranylcypromine) or within 2 weeks of MAO inhibitor use due to risk of serotonin syndrome.
Drug Interactions
MAO Inhibitors
Concurrent use is contraindicated due to increased risk of serotonin syndrome.
Serotonergic drugs (e.g., SSRIs, SNRIs, tricyclic antidepressants)
Increased risk of serotonin syndrome.
Adrenergic/Dopaminergic drugs (e.g., pseudoephedrine, epinephrine, dopamine)
Potentiates vasoconstrictor effects, leading to hypertensive crises.
Storage
Store at room temperature (20°C to 25°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
No specific antidote. Management involves symptomatic and supportive treatment. Hemodialysis may remove some of the drug.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk, as animal studies show adverse effects. Excreted in breast milk; caution advised or consider temporary discontinuation of breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months for unopened bottles. Refer to manufacturer's instructions for specific shelf life after reconstitution or opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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