Lipitin
Generic Name
Atorvastatin Calcium
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lipitin 10 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Lipitin 10 mg Tablet is a medication used to lower cholesterol and triglycerides in the blood. It belongs to a group of medicines called statins, which reduce the production of cholesterol by the liver. It helps to prevent heart disease and stroke.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily. Dose may be adjusted at 4-week intervals to a maximum of 80 mg once daily based on therapeutic response and tolerability.
Elderly
No specific dosage adjustment required; use lowest effective dose.
Renal_impairment
No dosage adjustment necessary for patients with renal impairment.
How to Take
Take orally once daily, with or without food, at any time of day.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the early, rate-limiting step in cholesterol biosynthesis. This inhibition leads to a decrease in hepatic cholesterol synthesis and, consequently, to an upregulation of hepatic LDL receptors, which increases the uptake and catabolism of LDL-C from the circulation.
Pharmacokinetics
Onset
Significant lipid-lowering effects observed within 2 weeks, maximal effect typically within 4 weeks.
Excretion
Primarily excreted in the bile following hepatic and/or extrahepatic metabolism; less than 2% is recovered in urine.
Half life
Approximately 14 hours for the parent drug, but the half-life of HMG-CoA reductase inhibitory activity is 20-30 hours due to active metabolites.
Absorption
Rapidly absorbed after oral administration; absolute bioavailability is approximately 14%.
Metabolism
Extensively metabolized in the liver by cytochrome P450 3A4 to active ortho- and parahydroxylated metabolites.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Hypersensitivity to atorvastatin or any component of the formulation.
Drug Interactions
Colchicine
Cases of myopathy, including rhabdomyolysis, have been reported with coadministration of atorvastatin and colchicine.
Cyclosporine, telaprevir, glecaprevir/pibrentasvir
Significantly increased atorvastatin exposure; avoid coadministration.
Gemfibrozil, other fibrates, niacin (lipid-modifying doses)
Increased risk of myopathy/rhabdomyolysis.
Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, protease inhibitors)
Increased atorvastatin plasma concentrations; limit atorvastatin dose.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin clearance.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. Women of childbearing potential should use adequate contraception. If pregnancy occurs, discontinue Lipitin immediately.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Hypersensitivity to atorvastatin or any component of the formulation.
Drug Interactions
Colchicine
Cases of myopathy, including rhabdomyolysis, have been reported with coadministration of atorvastatin and colchicine.
Cyclosporine, telaprevir, glecaprevir/pibrentasvir
Significantly increased atorvastatin exposure; avoid coadministration.
Gemfibrozil, other fibrates, niacin (lipid-modifying doses)
Increased risk of myopathy/rhabdomyolysis.
Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, protease inhibitors)
Increased atorvastatin plasma concentrations; limit atorvastatin dose.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin clearance.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. Women of childbearing potential should use adequate contraception. If pregnancy occurs, discontinue Lipitin immediately.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Atorvastatin has been extensively studied in numerous clinical trials demonstrating its efficacy in reducing LDL-C and cardiovascular events across various patient populations, including the ASCOT-LLA, MIRACL, and CARDS trials.
Lab Monitoring
- Liver function tests (ALT/AST) should be performed before initiation of therapy and periodically thereafter.
- Lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides) should be checked regularly.
- Creatine Kinase (CK) levels should be measured if muscle pain or weakness occurs.
Doctor Notes
- Prior to initiating therapy, evaluate for secondary causes of hyperlipidemia. A complete lipid profile should be obtained at baseline and periodically thereafter.
- Counsel patients on the importance of adhering to a cholesterol-lowering diet and regular exercise.
- Monitor LFTs at baseline, 12 weeks after initiation or dose escalation, and periodically thereafter. If AST/ALT >3x ULN, consider dose reduction or discontinuation.
- Educate patients on symptoms of myopathy and advise immediate reporting.
Patient Guidelines
- Take Lipitin exactly as prescribed by your doctor, usually once daily.
- Do not stop taking the medicine without consulting your doctor, even if you feel well.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine, to your doctor immediately.
- Avoid consuming large amounts of grapefruit juice while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Lipitin is not expected to impair the ability to drive or operate machinery. However, patients should be aware of possible side effects like dizziness.
Lifestyle Advice
- Maintain a healthy, low-fat diet as recommended by your doctor or dietitian.
- Engage in regular physical activity to help manage cholesterol levels.
- Quit smoking and limit alcohol consumption.
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