Lipitin
Generic Name
Atorvastatin Calcium
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lipitin 20 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Lipitin 20 mg Tablet contains Atorvastatin, a medication used to lower cholesterol and triglycerides in the blood. It helps prevent heart attacks, strokes, and other heart-related problems.
Uses & Indications
Dosage
Adults
Initial dose 10-20 mg once daily. Max 80 mg daily. For primary hypercholesterolemia, usual dose is 10 mg once daily.
Elderly
No dose adjustment required.
Renal_impairment
No dose adjustment required.
How to Take
Take orally once daily, with or without food, at any time of day, but preferably at the same time each day.
Mechanism of Action
Atorvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the early rate-limiting step in cholesterol biosynthesis. This results in a compensatory increase in the expression of hepatic LDL receptors, which leads to increased clearance of LDL-C from the blood.
Pharmacokinetics
Onset
Lipid-lowering effect seen within 2 weeks, maximal effect in 4 weeks.
Excretion
Primarily excreted in bile following hepatic and/or extrahepatic metabolism.
Half life
Elimination half-life of Atorvastatin is approximately 14 hours; active metabolites contribute to ~20-30 hours of HMG-CoA reductase inhibitory activity.
Absorption
Rapidly absorbed after oral administration; absolute bioavailability is approximately 14%.
Metabolism
Extensively metabolized by cytochrome P450 3A4 (CYP3A4) to active ortho- and parahydroxylated metabolites and various beta-oxidation products.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to Atorvastatin or any component of the medication
Drug Interactions
Gemfibrozil, other Fibrates, Niacin
Increased risk of myopathy/rhabdomyolysis.
Cyclosporine, Telaprevir, Tipranavir/Ritonavir
Increased risk of myopathy/rhabdomyolysis due to increased Atorvastatin exposure. Avoid concomitant use.
Clarithromycin, Itraconazole, Protease Inhibitors (e.g., Ritonavir)
Increased Atorvastatin plasma concentrations. Dose adjustment of Atorvastatin may be necessary.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, provide symptomatic and supportive measures. Monitor liver function and CK levels.
Pregnancy & Lactation
Category X in pregnancy (contraindicated due to potential fetal harm). Contraindicated during lactation as Atorvastatin is excreted in human milk.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy
- Lactation
- Hypersensitivity to Atorvastatin or any component of the medication
Drug Interactions
Gemfibrozil, other Fibrates, Niacin
Increased risk of myopathy/rhabdomyolysis.
Cyclosporine, Telaprevir, Tipranavir/Ritonavir
Increased risk of myopathy/rhabdomyolysis due to increased Atorvastatin exposure. Avoid concomitant use.
Clarithromycin, Itraconazole, Protease Inhibitors (e.g., Ritonavir)
Increased Atorvastatin plasma concentrations. Dose adjustment of Atorvastatin may be necessary.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, provide symptomatic and supportive measures. Monitor liver function and CK levels.
Pregnancy & Lactation
Category X in pregnancy (contraindicated due to potential fetal harm). Contraindicated during lactation as Atorvastatin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in all pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patent expired, generics available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., ASCOT, TNT, PROVE IT-TIMI 22) have demonstrated Atorvastatin's efficacy in reducing major cardiovascular events.
Lab Monitoring
- Liver function tests (ALT/AST) before treatment and periodically thereafter, or as clinically indicated.
- Creatine Kinase (CK) levels if muscle pain occurs.
Doctor Notes
- Counsel patients on lifestyle modifications (diet, exercise) along with drug therapy.
- Monitor LFTs and CK levels as per guidelines, especially if symptoms of myopathy arise.
- Avoid concomitant use with strong CYP3A4 inhibitors or adjust dose accordingly.
Patient Guidelines
- Take the tablet whole, do not crush or chew.
- Continue diet and exercise recommendations during therapy.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Lipitin is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Adopt a low-fat, low-cholesterol diet.
- Engage in regular physical activity.
- Maintain a healthy weight.
- Avoid smoking and limit alcohol intake.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Lipitin Brand
Other medicines available under the same brand name
