Lipitin
Generic Name
Atorvastatin Calcium
Manufacturer
PharmaCo Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lipitin 40 mg tablet | ৳ 24.07 | ৳ 240.70 |
Description
Overview of the medicine
Lipitin 40 mg Tablet contains Atorvastatin, which is used to lower high cholesterol and triglyceride levels in the blood. It helps prevent heart disease, strokes, and other cardiovascular problems.
Uses & Indications
Dosage
Adults
Initial dose is 10 or 20 mg once daily. Dosage can be adjusted based on lipid levels and therapeutic goals, ranging from 10 mg to a maximum of 80 mg once daily.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
Dosage adjustment is not required in patients with renal impairment.
How to Take
Take Lipitin 40 mg Tablet orally once daily, with or without food. It can be taken at any time of day, but it is recommended to take it at the same time each day.
Mechanism of Action
Atorvastatin inhibits HMG-CoA reductase, an enzyme crucial for cholesterol synthesis in the liver. By reducing cholesterol production, it decreases LDL (bad cholesterol) and VLDL levels, while increasing HDL (good cholesterol).
Pharmacokinetics
Onset
Lipid-lowering effects typically begin within 2 weeks, with maximal response usually observed by 4 weeks.
Excretion
Primarily eliminated in the bile following hepatic and/or extrahepatic metabolism. Less than 2% of a dose is recovered in the urine.
Half life
The apparent plasma elimination half-life of atorvastatin is approximately 14 hours, but the half-life of HMG-CoA reductase inhibitory activity is 20 to 30 hours due to active metabolites.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1 to 2 hours. Absolute bioavailability is approximately 12% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver by cytochrome P450 3A4 (CYP3A4) to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to atorvastatin or any component of the formulation
Drug Interactions
Niacin
Increased risk of myopathy/rhabdomyolysis.
Cyclosporine
Coadministration significantly increases atorvastatin plasma concentrations, increasing the risk of myopathy.
Oral contraceptives
May increase plasma concentrations of norethindrone and ethinyl estradiol.
Gemfibrozil and other fibrates
Increased risk of myopathy when coadministered with atorvastatin.
Macrolide antibiotics (e.g., Clarithromycin)
Increased exposure to atorvastatin and increased risk of myopathy/rhabdomyolysis.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, patients should be treated symptomatically and supportive measures instituted as required.
Pregnancy & Lactation
Lipitin is contraindicated during pregnancy and breastfeeding due to potential fetal harm and excretion into breast milk. Women of childbearing potential should use adequate contraception.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to atorvastatin or any component of the formulation
Drug Interactions
Niacin
Increased risk of myopathy/rhabdomyolysis.
Cyclosporine
Coadministration significantly increases atorvastatin plasma concentrations, increasing the risk of myopathy.
Oral contraceptives
May increase plasma concentrations of norethindrone and ethinyl estradiol.
Gemfibrozil and other fibrates
Increased risk of myopathy when coadministered with atorvastatin.
Macrolide antibiotics (e.g., Clarithromycin)
Increased exposure to atorvastatin and increased risk of myopathy/rhabdomyolysis.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for atorvastatin overdose. In the event of an overdose, patients should be treated symptomatically and supportive measures instituted as required.
Pregnancy & Lactation
Lipitin is contraindicated during pregnancy and breastfeeding due to potential fetal harm and excretion into breast milk. Women of childbearing potential should use adequate contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Pharmacies and Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Atorvastatin has been extensively studied in major clinical trials such as ASCOT-LLA, MIRACL, and TNT, demonstrating significant reductions in cardiovascular events, including myocardial infarction and stroke.
Lab Monitoring
- Liver function tests (LFTs) should be performed before initiating treatment and periodically thereafter.
- Lipid panel (Total cholesterol, LDL-C, HDL-C, Triglycerides) should be monitored regularly to assess treatment efficacy.
- Creatine Kinase (CK) levels should be measured if muscle pain or weakness occurs.
Doctor Notes
- Emphasize the importance of lifestyle modifications (diet, exercise) along with drug therapy for optimal lipid management.
- Educate patients on symptoms of myopathy and rhabdomyolysis and advise them to seek immediate medical attention if these occur.
- Regular monitoring of liver function tests and lipid profiles is essential.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor, preferably at the same time each day.
- Do not stop taking Lipitin without consulting your doctor, even if you feel well.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lipitin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that impair your concentration, avoid these activities.
Lifestyle Advice
- Follow a cholesterol-lowering diet recommended by your doctor or dietitian.
- Engage in regular physical activity as advised.
- Maintain a healthy weight, quit smoking, and limit alcohol consumption.
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