Lizorex
Generic Name
Linezolid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lizorex 100 mg suspension | ৳ 280.00 | N/A |
Description
Overview of the medicine
Lizorex 100 mg Suspension contains Linezolid, an antibiotic used to treat serious bacterial infections, especially those caused by Gram-positive bacteria that are resistant to other antibiotics, such as Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE). It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
600 mg (30 ml of 100 mg/5 ml suspension) every 12 hours for 10-14 days for most indications.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment; hemodialysis patients should receive dose after dialysis.
How to Take
Shake the suspension well before each use. Can be taken with or without food. Use an accurate measuring device provided with the medicine to ensure correct dosage.
Mechanism of Action
Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S ribosomal subunit, preventing the formation of the 70S initiation complex, which is essential for bacterial translation.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 1-2 hours.
Excretion
Approximately 65% of the dose is excreted renally (30% as unchanged drug, 35% as metabolites) and non-renally.
Half life
Approximately 4.5 to 5.5 hours.
Absorption
Rapid and extensive oral absorption with ~100% bioavailability.
Metabolism
Primarily by non-enzymatic oxidation to two inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Linezolid or any component of the formulation
- Concurrent use with MAO inhibitors (e.g., phenelzine, isocarboxazid) or within two weeks of discontinuing them
Drug Interactions
MAO Inhibitors
Increased risk of hypertensive reactions or serotonin syndrome.
Serotonergic drugs (SSRIs, SNRIs)
Increased risk of serotonin syndrome.
Adrenergic agents (e.g., pseudoephedrine, dopamine)
May enhance pressor effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
In case of overdose, seek emergency medical attention. Treatment should be symptomatic and supportive, including maintaining vital signs and monitoring for adverse effects. Hemodialysis may remove some Linezolid, but peritoneal dialysis has not been studied.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so caution is advised; decision to discontinue breastfeeding or the drug should consider the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Linezolid or any component of the formulation
- Concurrent use with MAO inhibitors (e.g., phenelzine, isocarboxazid) or within two weeks of discontinuing them
Drug Interactions
MAO Inhibitors
Increased risk of hypertensive reactions or serotonin syndrome.
Serotonergic drugs (SSRIs, SNRIs)
Increased risk of serotonin syndrome.
Adrenergic agents (e.g., pseudoephedrine, dopamine)
May enhance pressor effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
In case of overdose, seek emergency medical attention. Treatment should be symptomatic and supportive, including maintaining vital signs and monitoring for adverse effects. Hemodialysis may remove some Linezolid, but peritoneal dialysis has not been studied.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so caution is advised; decision to discontinue breastfeeding or the drug should consider the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (unopened). Once opened, use within 28 days.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by health authorities
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Linezolid in treating various Gram-positive bacterial infections, including those resistant to other antibiotics. Studies focused on its use in hospital-acquired and community-acquired pneumonia, skin and skin structure infections, and VRE infections across different age groups, including pediatric populations.
Lab Monitoring
- Complete Blood Count (CBC) weekly, especially for patients receiving therapy for longer than 2 weeks
- Liver function tests (LFTs) periodically
- Renal function tests periodically
Doctor Notes
- Monitor Complete Blood Count (CBC) weekly, particularly in patients on prolonged therapy (>2 weeks) or with pre-existing myelosuppression.
- Advise patients on the risk of serotonin syndrome when co-administered with serotonergic drugs and to seek immediate medical attention for symptoms.
- Counsel patients to avoid foods and beverages high in tyramine to minimize the risk of hypertensive reactions.
- Be aware of potential for peripheral and optic neuropathy with extended use.
- Ensure proper administration technique and accurate dosing, especially in pediatric patients, using the provided measuring device.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Shake the suspension well before each use.
- Report any new or worsening symptoms, especially visual changes or numbness/tingling in hands/feet, to your doctor immediately.
- Avoid consuming large amounts of tyramine-rich foods while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or visual disturbances. If you experience these effects, avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Follow a balanced diet as advised by your healthcare provider.
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