Lizorex
Generic Name
Levofloxacin
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lizorex 400 mg tablet | ৳ 60.00 | ৳ 600.00 |
Description
Overview of the medicine
Lizorex 400 mg Tablet contains Levofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typically 400 mg once daily, depending on the infection type and severity.
Elderly
No specific dose adjustment required unless severe renal impairment is present.
Renal_impairment
Dosage adjustment necessary for creatinine clearance <50 mL/min. For CrCl 20-49 mL/min: 200 mg every 24 hours. For CrCl 10-19 mL/min: 100 mg every 24 hours.
How to Take
Take orally with or without food. Do not crush or chew the tablet. Maintain adequate hydration.
Mechanism of Action
Inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 6-8 hours.
Absorption
Rapid and almost complete absorption from the gastrointestinal tract. Bioavailability is approximately 99%.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy or other seizure disorders
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR.
Corticosteroids
Increased risk of tendon rupture when co-administered with fluoroquinolones.
QT-prolonging drugs
Increased risk of QT interval prolongation and arrhythmias.
Antacids containing magnesium or aluminum, sucralfate, iron supplements
Reduced absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS effects (confusion, seizures), QT prolongation. Treatment is symptomatic and supportive. Gastric lavage and hydration may be helpful.
Pregnancy & Lactation
Generally not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy or other seizure disorders
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR.
Corticosteroids
Increased risk of tendon rupture when co-administered with fluoroquinolones.
QT-prolonging drugs
Increased risk of QT interval prolongation and arrhythmias.
Antacids containing magnesium or aluminum, sucralfate, iron supplements
Reduced absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include CNS effects (confusion, seizures), QT prolongation. Treatment is symptomatic and supportive. Gastric lavage and hydration may be helpful.
Pregnancy & Lactation
Generally not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies and Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Levofloxacin for approved indications.
Lab Monitoring
- Renal function in patients with impairment
- Liver function tests if clinically indicated
- INR if co-administering with warfarin
- QT interval monitoring in patients at risk
Doctor Notes
- Advise patients on the importance of completing the full course.
- Counsel patients about potential tendon issues and to report any pain immediately.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Avoid excessive sunlight or artificial UV light, as it may cause photosensitivity.
- Inform your doctor about any history of tendon problems, epilepsy, or heart conditions.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
May cause dizziness, lightheadedness, or visual disturbances. Avoid driving or operating machinery if you experience these effects.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Lizorex Brand
Other medicines available under the same brand name
