Adults

For children 2-5 years: 5 mg (5 mL of 1 mg/mL solution) once daily. For children 6 years and older: 10 mg (10 mL of 1 mg/mL solution) once daily. Consult a physician for exact dosing for Loridon 5 mg Pediatric Drop.

Elderly

Not applicable for pediatric drop. Refer to adult formulations for elderly dosage.

Renal_impairment

For patients with severe renal impairment (glomerular filtration rate < 30 mL/min), the initial dose should be reduced to 5 mg (5 mL) every other day. Consult physician.

Onset

Onset of action typically occurs within 1-3 hours.

Excretion

Approximately 40% of the dose is excreted in the urine and 42% in the feces over 10 days, primarily as conjugated metabolites.

Half life

Loratadine has a plasma half-life of approximately 8-11 hours. Its active metabolite, desloratadine, has a longer half-life of 17-24 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached within 1-2 hours for loratadine and 1.5-3.7 hours for desloratadine (active metabolite).

Metabolism

Loratadine is extensively metabolized in the liver by cytochrome P450 3A4 and 2D6 into its major active metabolite, descarboethoxyloratadine (desloratadine).

Cimetidine

Use with cimetidine may slightly increase loratadine plasma levels; clinical significance is generally negligible.

Erythromycin

Co-administration with erythromycin may lead to increased plasma concentrations of loratadine and desloratadine, but without clinically significant changes in the ECG or adverse event profile.

Ketoconazole

Concomitant use with ketoconazole may increase plasma concentrations of loratadine and its active metabolite, desloratadine. However, no clinically significant adverse effects have been reported.