Lubilax
Generic Name
Sodium Picosulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lubilax 8 mcg capsule | ৳ 15.05 | ৳ 150.50 |
| lubilax 24 mcg capsule | ৳ 40.12 | ৳ 401.20 |
Description
Overview of the medicine
Lubilax is a stimulant laxative containing Sodium Picosulfate, primarily used for the short-term treatment of constipation. It helps to stimulate bowel movements.
Uses & Indications
Dosage
Adults
Adults and adolescents over 12 years: 5-10 mg orally at night, usually with a glass of water. Do not exceed 10 mg per day.
Elderly
Start with the lowest effective dose (e.g., 5 mg) and adjust as needed.
Renal_impairment
No specific dose adjustment is required in mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally, preferably at night, to produce a bowel movement the following morning. Swallow the tablet whole with water.
Mechanism of Action
Sodium Picosulfate is a prodrug converted by colonic bacteria into an active compound (BHPM) that stimulates the enteric neurons, increasing peristalsis and promoting fluid accumulation in the colon, thereby facilitating bowel movement.
Pharmacokinetics
Onset
6-12 hours after oral administration.
Excretion
Primarily excreted in feces; small amounts of glucuronides excreted renally.
Half life
Active metabolite (BHPM) has a half-life of 6-10 hours.
Absorption
Poorly absorbed systemically. Primarily acts locally in the colon after hydrolysis by bacteria.
Metabolism
Hydrolyzed by colonic bacteria to the active compound bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).
Side Effects
Contraindications
- Intestinal obstruction or paralytic ileus
- Acute inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis)
- Severe dehydration
- Acute abdominal pain (e.g., appendicitis)
- Hypersensitivity to Sodium Picosulfate or any component
Drug Interactions
Antibiotics
May reduce the laxative effect by altering the colonic bacterial flora.
Diuretics and Adrenocorticosteroids
Concomitant use may increase the risk of electrolyte imbalance, especially hypokalemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe diarrhea, abdominal cramps, and significant fluid and electrolyte loss (especially hypokalemia). Management is symptomatic and supportive, including fluid and electrolyte replacement.
Pregnancy & Lactation
Use during pregnancy is not recommended unless clearly necessary and under medical supervision. Small amounts of active metabolite may pass into breast milk, but adverse effects on the infant are unlikely with short-term use. Consult a doctor.
Side Effects
Contraindications
- Intestinal obstruction or paralytic ileus
- Acute inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis)
- Severe dehydration
- Acute abdominal pain (e.g., appendicitis)
- Hypersensitivity to Sodium Picosulfate or any component
Drug Interactions
Antibiotics
May reduce the laxative effect by altering the colonic bacterial flora.
Diuretics and Adrenocorticosteroids
Concomitant use may increase the risk of electrolyte imbalance, especially hypokalemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe diarrhea, abdominal cramps, and significant fluid and electrolyte loss (especially hypokalemia). Management is symptomatic and supportive, including fluid and electrolyte replacement.
Pregnancy & Lactation
Use during pregnancy is not recommended unless clearly necessary and under medical supervision. Small amounts of active metabolite may pass into breast milk, but adverse effects on the infant are unlikely with short-term use. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Standard clinical trials support its efficacy and safety for short-term constipation. Further trials may explore specific populations or long-term effects.
Lab Monitoring
- Electrolyte levels (especially potassium) may be monitored in prolonged or excessive use.
- Renal function in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients on lifestyle modifications for constipation (diet, fluid intake, exercise).
- Emphasize short-term use to avoid dependence and potential long-term complications.
- Rule out underlying medical conditions causing constipation before recommending stimulant laxatives.
Patient Guidelines
- Do not use for more than 5 consecutive days without medical advice.
- Drink plenty of fluids to prevent dehydration.
- Consult a doctor if constipation persists or worsens.
- Do not chew the tablet; swallow whole.
Missed Dose Advice
If a dose is missed, take it as soon as you remember if it's still nighttime. If it's morning, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Usually no effect. However, if dizziness or fainting occurs as a side effect, avoid driving or operating machinery.
Lifestyle Advice
- Increase dietary fiber intake.
- Maintain adequate fluid intake.
- Engage in regular physical activity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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