Lumona
Generic Name
Levocetirizine Dihydrochloride
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lumona 10 mg tablet | ৳ 12.00 | ৳ 168.00 |
| lumona 4 mg oral granules | ৳ 8.00 | N/A |
Description
Overview of the medicine
Lumona contains Levocetirizine Dihydrochloride, a third-generation antihistamine used to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
5 mg once daily, taken in the evening.
Elderly
Dose adjustment may be necessary in elderly patients with impaired renal function.
Renal_impairment
Reduced dosage for patients with mild, moderate, or severe renal impairment; contraindicated in end-stage renal disease.
How to Take
May be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Levocetirizine, the R-enantiomer of cetirizine, is a potent and selective H1-receptor antagonist. It blocks the effects of histamine by competitively binding to peripheral H1-receptors, thereby reducing allergic symptoms.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in the urine (approximately 85.4% of the dose).
Half life
Approximately 7-10 hours in adults
Absorption
Rapidly and extensively absorbed after oral administration, peak plasma concentrations reached within 0.9-1 hour.
Metabolism
Minimally metabolized in the liver (less than 14% of the dose).
Side Effects
Contraindications
- Hypersensitivity to levocetirizine or any component of the formulation
- Patients with end-stage renal disease (CrCl < 10 mL/min) or undergoing hemodialysis
Drug Interactions
Ritonavir
Increases plasma levels of levocetirizine.
Central Nervous System (CNS) Depressants (e.g., alcohol, sedatives)
Increased CNS depression.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include somnolence in adults and agitation or restlessness followed by somnolence in children. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution is advised in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine or any component of the formulation
- Patients with end-stage renal disease (CrCl < 10 mL/min) or undergoing hemodialysis
Drug Interactions
Ritonavir
Increases plasma levels of levocetirizine.
Central Nervous System (CNS) Depressants (e.g., alcohol, sedatives)
Increased CNS depression.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include somnolence in adults and agitation or restlessness followed by somnolence in children. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution is advised in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Patent expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of levocetirizine for its approved indications.
Lab Monitoring
- No specific routine lab monitoring required. Renal function should be monitored in patients with renal impairment.
Doctor Notes
- Advise patients to take in the evening to mitigate somnolence.
- Caution in patients with epilepsy due to potential for seizure exacerbation (though rare).
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid driving or operating machinery if you experience somnolence.
- Consult your doctor if symptoms persist or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness. Patients should be warned against engaging in activities requiring complete mental alertness, such as driving a car or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good hygiene to reduce exposure to allergens.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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