Macery
Generic Name
Macerycin
Manufacturer
Medipharm Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| macery 500 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Macery 500 mg Tablet contains Macerycin, a broad-spectrum antibacterial agent used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 3-7 days, depending on infection type and severity.
Elderly
No specific dose adjustment required unless severe renal or hepatic impairment is present.
Renal_impairment
Mild to moderate (CrCl >30 mL/min): No dose adjustment. Severe (CrCl <30 mL/min): Consider dose reduction or extended dosing interval.
How to Take
Oral, with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Macerycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptide chains.
Pharmacokinetics
Onset
1-2 hours
Excretion
Mainly via bile and feces (approximately 80%); a small portion via urine (approximately 20%).
Half life
8-12 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability ~60%. Peak plasma concentration reached in 1-2 hours.
Metabolism
Primarily hepatic via CYP3A4 enzymes, with some active metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Macerycin or any other macrolide antibiotics
- •Severe hepatic impairment
- •Concomitant use with drugs known to prolong the QT interval (e.g., cisapride, terfenadine)
Drug Interactions
Digoxin
Increased digoxin levels, requiring monitoring.
Warfarin
Increased anticoagulant effect, monitor INR closely.
Theophylline
Increased serum levels of theophylline, potentially leading to toxicity.
Ergot alkaloids (e.g., ergotamine)
Potentiates vasoconstriction, leading to ergotism.
Storage
Store below 30°C in a dry place, away from direct sunlight, heat, and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal pain, and reversible hearing loss. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefit outweighs the potential risk. Macerycin is excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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