Macrozith
Generic Name
Azithromycin 200 mg/5ml Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| macrozith 200 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Macrozith-200-mg-suspension is an antibiotic medicine containing Azithromycin, used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not the primary formulation for adults; consult physician for adult formulations (e.g., tablets).
Elderly
Not applicable for this suspension form. Refer to adult tablet/capsule guidelines if needed.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. Caution advised in severe impairment.
How to Take
Shake well before use. Administer orally once daily with or without food. Use an oral syringe or measuring spoon for accurate dosing.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thus preventing bacterial growth.
Pharmacokinetics
Onset
Within 2-3 hours
Excretion
Primarily excreted unchanged in bile; a small portion via urine.
Half life
Approximately 2-4 days (tissue half-life is much longer)
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 37%.
Metabolism
Undergoes hepatic metabolism, primarily N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin serum levels.
Warfarin
Increased anticoagulant effect; monitor INR.
Nelfinavir
Increased azithromycin serum concentrations.
Antacids (containing aluminum or magnesium)
Decreased peak serum concentrations of azithromycin; take azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive. Gastric lavage and supportive measures as necessary.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin serum levels.
Warfarin
Increased anticoagulant effect; monitor INR.
Nelfinavir
Increased azithromycin serum concentrations.
Antacids (containing aluminum or magnesium)
Decreased peak serum concentrations of azithromycin; take azithromycin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is symptomatic and supportive. Gastric lavage and supportive measures as necessary.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened); 10 days after reconstitution
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and validated in numerous clinical trials for its efficacy and safety in treating various bacterial infections.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- Kidney function tests (in severe renal impairment)
- INR (if co-administered with warfarin)
- ECG (in patients at risk for QT prolongation)
Doctor Notes
- Counsel parents/guardians on proper administration and importance of completing the full course.
- Advise to report any signs of allergic reaction or severe diarrhea immediately.
- Monitor for QT prolongation in high-risk patients.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not save leftover medication for future infections.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; advise caution when driving or operating machinery until effects are known.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment.
- Rest sufficiently.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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