Macrozith
Generic Name
Azithromycin 500 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| macrozith 500 mg tablet | ৳ 34.00 | ৳ 204.00 |
Description
Overview of the medicine
Macrozith 500 mg Tablet contains Azithromycin, a macrolide antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For respiratory tract, skin and soft tissue infections: 500 mg once daily for 3 days, or 500 mg on Day 1 followed by 250 mg once daily on Days 2-5. For Chlamydia trachomatis: 1000 mg as a single oral dose.
Elderly
No dosage adjustment needed for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment (creatinine clearance >10-80 mL/min).
How to Take
Take Macrozith 500 mg Tablet orally, with or without food. To minimize gastric upset, it can be taken with food.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with the translation of mRNA.
Pharmacokinetics
Onset
Peak plasma concentrations reached in 2-3 hours.
Excretion
Mainly excreted unchanged in bile; a small amount is excreted via urine.
Half life
Prolonged terminal elimination half-life of 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Primarily hepatic, but limited metabolism to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels, monitor digoxin concentrations.
Antacids
Reduced peak plasma concentrations of azithromycin; administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Increased anticoagulant effect, monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Azithromycin is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels, monitor digoxin concentrations.
Antacids
Reduced peak plasma concentrations of azithromycin; administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Increased anticoagulant effect, monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Azithromycin is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA/DGDA Approved
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of azithromycin for its approved indications.
Lab Monitoring
- Liver function tests (LFTs) if prolonged treatment or hepatic dysfunction is suspected.
- Renal function tests if severe renal impairment exists.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent resistance.
- Caution in patients with known QT prolongation or risk factors for Torsades de Pointes.
- Advise patients to report any severe gastrointestinal side effects immediately.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Do not share this medication with others.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Macrozith may cause dizziness in some individuals. Exercise caution when driving or operating machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain good hydration while on antibiotic treatment.
- Avoid alcohol consumption during treatment, especially for infections that may be exacerbated by it.
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