Maczith
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maczith 250 mg capsule | ৳ 25.00 | ৳ 75.00 |
Description
Overview of the medicine
Maczith 250 mg Capsule contains Azithromycin, a macrolide antibiotic, used to treat a wide range of bacterial infections including respiratory, skin, and sexually transmitted infections.
Uses & Indications
Dosage
Adults
For most infections: 500 mg once daily for 3 days, or 500 mg on Day 1 followed by 250 mg once daily for 4 days. For Chlamydia: 1 g as a single dose.
Elderly
No specific dosage adjustment is generally needed, but monitor renal and hepatic function.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Maczith capsules can be taken with or without food. For optimal absorption, some sources suggest taking it one hour before or two hours after a meal.
Mechanism of Action
Azithromycin works by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis and preventing bacterial growth.
Pharmacokinetics
Onset
Varies with infection type, generally within hours to days for clinical effect.
Excretion
Primarily excreted unchanged in the bile; a small amount is excreted in urine.
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Partially metabolized in the liver to inactive metabolites, primarily via N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin levels; monitor digoxin serum levels.
Warfarin
Increased anticoagulant effect; monitor PT/INR closely.
Nelfinavir
Significant increase in azithromycin concentration; no dosage adjustment for azithromycin is recommended.
Antacids (containing aluminum or magnesium)
May decrease peak serum concentrations of azithromycin; take azithromycin at least 2 hours before or after antacids.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose typically include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment should be symptomatic and supportive, including general supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Azithromycin is excreted in human breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin levels; monitor digoxin serum levels.
Warfarin
Increased anticoagulant effect; monitor PT/INR closely.
Nelfinavir
Significant increase in azithromycin concentration; no dosage adjustment for azithromycin is recommended.
Antacids (containing aluminum or magnesium)
May decrease peak serum concentrations of azithromycin; take azithromycin at least 2 hours before or after antacids.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose typically include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment should be symptomatic and supportive, including general supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Azithromycin is excreted in human breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across a broad spectrum of bacterial infections. Research continues on its potential use in other conditions.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or pre-existing hepatic impairment.
- Renal function tests if severe renal impairment.
Doctor Notes
- Emphasize the importance of completing the full course to prevent recurrence and resistance.
- Counsel patients on potential gastrointestinal side effects and advise taking with food if tolerated.
- Monitor for signs of C. difficile infection, especially in patients presenting with new-onset diarrhea after antibiotic use.
- Consider the risk of QT prolongation in patients with known cardiac risk factors or concomitant medications.
Patient Guidelines
- Complete the entire course of medication as prescribed by your doctor, even if your symptoms improve sooner.
- Do not share this medication with others, even if they have similar symptoms.
- Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking.
- Report any severe side effects like persistent diarrhea, yellowing of skin/eyes, or heart palpitations immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Maczith may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene practices to prevent the spread of infection.
- Stay well-hydrated.
- Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.
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