Maxsulin N
Generic Name
Insulin Isophane (NPH)
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxsulin n 40 iu injection | ৳ 195.00 | N/A |
| maxsulin n 100 iu injection | ৳ 222.00 | N/A |
Description
Overview of the medicine
Maxsulin N contains Insulin Isophane (NPH), a long-acting insulin used to improve blood sugar control in adults and children with diabetes mellitus. It helps the body use sugar for energy.
Uses & Indications
Dosage
Adults
Individualized dosage based on blood glucose levels and metabolic needs. Typically administered once or twice daily, 30-45 minutes before a meal.
Elderly
Dosage should be individualized, starting with a lower dose and careful monitoring due to potential for hypoglycemia and renal/hepatic impairment.
Renal_impairment
Dosage adjustment may be necessary. Close monitoring of blood glucose is recommended.
How to Take
Administer by subcutaneous injection into the abdomen, thigh, upper arm, or buttock. Rotate injection sites within the same region to prevent lipodystrophy. Do not administer intravenously.
Mechanism of Action
NPH insulin is an intermediate-acting insulin. It works by replacing the insulin the body normally produces, helping sugar (glucose) get from the blood into cells where it's used for energy. It also inhibits glucose production by the liver.
Pharmacokinetics
Onset
1.5-4 hours
Excretion
Primarily renal, with a small amount excreted in bile.
Half life
Not directly measurable due to variable absorption; duration of action is more relevant.
Absorption
Slowly absorbed from subcutaneous tissue due to its crystalline suspension with protamine and zinc. Absorption rate can vary significantly.
Metabolism
Primarily metabolized by insulinase enzymes in the liver and kidneys.
Side Effects
Contraindications
- Hypoglycemia
- Hypersensitivity to insulin or any component of the formulation
Drug Interactions
Beta-blockers
May mask symptoms of hypoglycemia.
Corticosteroids, diuretics, thyroid hormones
May decrease insulin's glucose-lowering effect.
Oral antidiabetics, ACE inhibitors, salicylates
May increase insulin's glucose-lowering effect.
Storage
Store unopened vials/cartridges in a refrigerator (2°C-8°C). Do not freeze. Protect from light. In-use vials/cartridges can be kept at room temperature (below 30°C) for up to 28 days.
Overdose
Severe hypoglycemia may occur. Mild episodes can be treated with oral glucose. Severe episodes require IV glucose or glucagon injection. Hospitalization may be necessary.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy. Dosage requirements usually change throughout pregnancy and lactation. Consult a doctor.
Side Effects
Contraindications
- Hypoglycemia
- Hypersensitivity to insulin or any component of the formulation
Drug Interactions
Beta-blockers
May mask symptoms of hypoglycemia.
Corticosteroids, diuretics, thyroid hormones
May decrease insulin's glucose-lowering effect.
Oral antidiabetics, ACE inhibitors, salicylates
May increase insulin's glucose-lowering effect.
Storage
Store unopened vials/cartridges in a refrigerator (2°C-8°C). Do not freeze. Protect from light. In-use vials/cartridges can be kept at room temperature (below 30°C) for up to 28 days.
Overdose
Severe hypoglycemia may occur. Mild episodes can be treated with oral glucose. Severe episodes require IV glucose or glucagon injection. Hospitalization may be necessary.
Pregnancy & Lactation
Insulin is the preferred treatment for diabetes in pregnancy. Dosage requirements usually change throughout pregnancy and lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 2-3 years at 2°C-8°C. After opening/in-use: 28 days at room temperature (below 30°C).
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by health authorities worldwide
Patent Status
Generics available, patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Numerous clinical trials have established its efficacy and safety in diabetes management.
Lab Monitoring
- Blood glucose levels (regularly)
- HbA1c (quarterly)
- Kidney function (periodically)
- Liver function (periodically)
Doctor Notes
- Emphasize proper patient education on injection technique and hypoglycemia management.
- Regular monitoring of blood glucose and HbA1c is essential.
- Caution in patients with renal or hepatic impairment due to altered insulin clearance.
Patient Guidelines
- Always check the insulin label carefully before each injection.
- Never share needles or insulin pens.
- Carry a source of fast-acting sugar to treat hypoglycemia.
- Learn proper injection technique.
Missed Dose Advice
If a dose is missed, check blood sugar levels and consult a doctor. Do not take a double dose to make up for a missed one. If it's close to the next scheduled dose, skip the missed dose and resume your regular schedule.
Driving Precautions
Hypoglycemia can impair driving ability. Patients should be aware of hypoglycemia symptoms and check blood sugar before driving. If symptoms occur, do not drive.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular physical activity.
- Monitor blood sugar levels as advised.
- Avoid smoking and excessive alcohol.
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Global Brand Names
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