Memanto
Generic Name
Memantine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| memanto 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
| memanto 10 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Memanto (Memantine) is a medication used to treat moderate to severe Alzheimer's disease. It helps to improve memory, awareness, and the ability to perform daily functions by affecting certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily, gradually increased by 5 mg increments weekly to a target maintenance dose of 10 mg twice daily (20 mg/day).
Elderly
No specific dose adjustment is needed for elderly patients with normal renal function.
Renal_impairment
Dose adjustment required. For moderate renal impairment (CrCl 30-49 mL/min), maximum dose 10 mg/day. For severe renal impairment (CrCl 5-29 mL/min), maximum dose 5 mg/day.
How to Take
Memanto tablets should be taken orally, with or without food. It is usually taken once or twice a day. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist. It blocks the effects of excessive glutamate, a neurotransmitter that can lead to neuronal dysfunction and death in Alzheimer's disease.
Pharmacokinetics
Onset
Clinical effects may take weeks to months to become apparent.
Excretion
Primarily excreted renally (via urine), with approximately 48% excreted unchanged.
Half life
Approximately 60-80 hours.
Absorption
Well absorbed after oral administration, peak plasma concentration reached in 3-7 hours.
Metabolism
Minimal hepatic metabolism; some metabolites are formed, but primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to memantine or any component of the formulation
Drug Interactions
Sodium bicarbonate
May reduce the renal excretion of memantine, leading to increased plasma levels.
Carbonic anhydrase inhibitors (e.g., acetazolamide)
May reduce the renal excretion of memantine, leading to increased plasma levels.
Antagonists of NMDA receptors (e.g., amantadine, ketamine, dextromethorphan)
Concurrent use with other NMDA antagonists may increase the frequency and severity of adverse reactions.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, somnolence, stupor, and seizures. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is unknown if memantine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to memantine or any component of the formulation
Drug Interactions
Sodium bicarbonate
May reduce the renal excretion of memantine, leading to increased plasma levels.
Carbonic anhydrase inhibitors (e.g., acetazolamide)
May reduce the renal excretion of memantine, leading to increased plasma levels.
Antagonists of NMDA receptors (e.g., amantadine, ketamine, dextromethorphan)
Concurrent use with other NMDA antagonists may increase the frequency and severity of adverse reactions.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, somnolence, stupor, and seizures. Treatment is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is unknown if memantine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generic versions available, original patent expired
Clinical Trials
Numerous clinical trials have demonstrated Memantine's efficacy and safety in improving cognitive and functional outcomes in patients with moderate to severe Alzheimer's disease.
Lab Monitoring
- Routine monitoring of renal function (CrCl) for patients with renal impairment.
Doctor Notes
- Titrate dose slowly to minimize adverse effects.
- Assess renal function before initiation and periodically during treatment.
- Counsel caregivers on the importance of adherence and potential side effects.
Patient Guidelines
- Take Memanto regularly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Memantine may cause dizziness or confusion. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Memanto does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise routine.
- Engage in mentally stimulating activities to support cognitive function.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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