Mexclav
Generic Name
Amoxicillin and Clavulanic Acid
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mexclav 500 mg tablet | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Mexclav 500 mg Tablet is a combination antibiotic used to treat a wide variety of bacterial infections. It contains amoxicillin, a penicillin-type antibiotic, and clavulanic acid, a beta-lactamase inhibitor, which helps amoxicillin work more effectively against bacteria that produce beta-lactamase.
Uses & Indications
Dosage
Adults
One 500 mg/125 mg tablet every 8 hours, or as directed by physician. For severe infections, dosage may be increased.
Elderly
Similar to adult dosage, but caution with renal impairment.
Renal_impairment
Dosage adjustment required based on creatinine clearance; generally reduced frequency or dose.
How to Take
Take orally with a glass of water, preferably at the start of a meal to minimize potential gastrointestinal intolerance. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Clavulanic acid irreversibly binds to and inactivates beta-lactamase enzymes produced by bacteria, which would otherwise degrade amoxicillin, thus protecting amoxicillin from hydrolysis.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine (amoxicillin) and as metabolites (clavulanic acid).
Half life
Approximately 1-1.5 hours for both amoxicillin and clavulanic acid.
Absorption
Well absorbed from the gastrointestinal tract, food can reduce absorption of clavulanic acid slightly but overall absorption is good.
Metabolism
Amoxicillin is minimally metabolized; clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics
- History of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction
- Infectious mononucleosis (increased risk of rash)
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Allopurinol
Increased incidence of rash, particularly in patients with hyperuricemia.
Methotrexate
Reduced renal tubular secretion of methotrexate, potentially increasing toxicity.
Oral contraceptives
May reduce efficacy of oral contraceptives (advise additional contraception).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset, electrolyte imbalance, crystalluria, and convulsions. Treatment is symptomatic and supportive; hemodialysis can remove amoxicillin/clavulanic acid from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use with caution and only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics
- History of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction
- Infectious mononucleosis (increased risk of rash)
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Allopurinol
Increased incidence of rash, particularly in patients with hyperuricemia.
Methotrexate
Reduced renal tubular secretion of methotrexate, potentially increasing toxicity.
Oral contraceptives
May reduce efficacy of oral contraceptives (advise additional contraception).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset, electrolyte imbalance, crystalluria, and convulsions. Treatment is symptomatic and supportive; hemodialysis can remove amoxicillin/clavulanic acid from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use with caution and only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies globally, including FDA (US) and DGDA (Bangladesh)
Patent Status
Generic available (Original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials establishing its efficacy and safety against a broad range of bacterial infections.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment or prolonged treatment)
- Renal function tests (for patients with renal impairment)
- Complete blood count (for prolonged treatment)
Doctor Notes
- Assess for penicillin allergy before prescribing.
- Monitor liver function in patients with pre-existing hepatic conditions.
- Advise patients to complete the full course to prevent resistance.
Patient Guidelines
- Take medicine as prescribed and complete the full course.
- Do not stop taking the medicine even if you feel better.
- Report any severe diarrhea or allergic reactions immediately.
- Take with food to reduce stomach upset.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, it does not affect the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, avoid driving.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment.
- Practice good hygiene to prevent reinfection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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