Take orally with or after food to minimize gastrointestinal upset. Swallow the tablet whole with water. Do not chew or crush.

Metronidazole enters the cell of anaerobic bacteria and sensitive protozoa, where it is reduced by electron transport proteins. This reduction leads to the formation of short-lived nitroso free radicals which damage DNA, inhibiting nucleic acid synthesis and causing cell death.

• •Hypersensitivity to metronidazole or other nitroimidazole derivatives
• •First trimester of pregnancy (relative contraindication for trichomoniasis)

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms include nausea, vomiting, ataxia, and mild disorientation. Management is symptomatic and supportive; no specific antidote exists. Gastric lavage may be considered.

Pregnancy Category B. Generally considered safe during the second and third trimesters. Caution advised during the first trimester. Metronidazole is excreted into breast milk; breastfeeding should be temporarily discontinued during treatment or an alternative drug considered.