Montelon
Generic Name
Montelukast
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| montelon 5 mg tablet | ৳ 9.00 | ৳ 90.00 |
| montelon 10 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Montelon (Montelukast) is a leukotriene receptor antagonist used for the prevention and long-term treatment of asthma, relief of symptoms of seasonal and perennial allergic rhinitis, and prevention of exercise-induced bronchoconstriction.
Uses & Indications
Dosage
Adults
For asthma or allergic rhinitis: 10 mg orally once daily in the evening.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required in patients with renal impairment.
Hepatic_impairment
No dosage adjustment is required in patients with mild to moderate hepatic impairment. For severe hepatic impairment, data is not available.
Pediatric_2_to_5_years
4 mg chewable tablet or granule once daily in the evening for asthma or allergic rhinitis.
Pediatric_6_to_14_years
5 mg chewable tablet once daily in the evening for asthma or allergic rhinitis, or 10 mg for EIB.
Pediatric_over_15_years
Same as adult dosage (10 mg tablet).
How to Take
Take Montelon once daily in the evening. It can be taken with or without food. Chewable tablets should be chewed completely before swallowing. Granules can be mixed with a spoonful of soft food (e.g., applesauce, rice, or ice cream) or dissolved in a small amount of breast milk or formula.
Mechanism of Action
Montelukast selectively antagonizes the CysLT1 receptor. The cysteinyl leukotrienes (LTC4, LTD4, LTEE4) are potent inflammatory eicosanoids released from various cells including mast cells and eosinophils. They bind to CysLT1 receptors and cause bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment. By blocking these receptors, Montelukast reduces these effects.
Pharmacokinetics
Onset
Clinical effects generally seen within one day.
Excretion
Primarily excreted in the feces via bile (approximately 86%), with less than 0.2% excreted in urine.
Half life
Plasma half-life ranges from 2.7 to 5.5 hours in healthy adults.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved in approximately 2 to 4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP2C8, CYP3A4, CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
- Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus.
Drug Interactions
Rifampin
May decrease the plasma concentration of montelukast.
Gemfibrozil
May increase the systemic exposure of montelukast.
Phenobarbital
May decrease the AUC of montelukast by approximately 40%.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
In the event of an overdose, symptomatic and supportive measures should be employed. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant women have not shown an increased risk of birth defects. Use during lactation should be done with caution, as it is unknown whether montelukast is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
- Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus.
Drug Interactions
Rifampin
May decrease the plasma concentration of montelukast.
Gemfibrozil
May increase the systemic exposure of montelukast.
Phenobarbital
May decrease the AUC of montelukast by approximately 40%.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
In the event of an overdose, symptomatic and supportive measures should be employed. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant women have not shown an increased risk of birth defects. Use during lactation should be done with caution, as it is unknown whether montelukast is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Montelukast has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in asthma and allergic rhinitis across various age groups.
Lab Monitoring
- Routine laboratory monitoring is generally not required. Liver function tests may be considered if signs or symptoms of hepatic dysfunction develop.
Doctor Notes
- Emphasize to patients that Montelon is a prophylactic treatment, not for acute relief.
- Educate patients and caregivers about potential neuropsychiatric events and the importance of reporting them.
- Ensure proper administration technique for chewable tablets and granules, especially in pediatric patients.
Patient Guidelines
- Take Montelon once daily, even when you feel well.
- Do not use Montelon for an acute asthma attack. Use your rescue inhaler for sudden breathing problems.
- Report any mood or behavior changes to your doctor immediately.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose.
Driving Precautions
Montelukast may cause dizziness or drowsiness in some patients. If these effects occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known asthma triggers and allergens. Maintain a healthy lifestyle with regular exercise and a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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