Montene
Generic Name
Montelukast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| montene 4 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Montene 4 mg tablet contains Montelukast, a leukotriene receptor antagonist, used for the treatment of asthma and allergic rhinitis.
Uses & Indications
Dosage
Adults
Not for adult use (adults typically use 10 mg daily).
Elderly
Not typically used in this strength for elderly; refer to 10 mg dosage for adults if applicable.
Renal_impairment
No dosage adjustment necessary for renal impairment.
Pediatric_2_5_years
One 4 mg chewable tablet once daily in the evening.
How to Take
Take orally once daily in the evening, with or without food. The 4 mg chewable tablet should be chewed thoroughly before swallowing.
Mechanism of Action
Montelukast selectively inhibits the cysteinyl leukotriene 1 (CysLT1) receptor, blocking the action of leukotrienes, which are inflammatory mediators involved in asthma and allergic rhinitis.
Pharmacokinetics
Onset
Generally within one day for asthma symptoms.
Excretion
Primarily excreted in the feces via bile (approximately 86%), with less than 0.2% excreted in urine.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% for a 5 mg chewable tablet.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4, CYP2C9, and CYP2C8).
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation
Drug Interactions
Rifampin
May decrease montelukast plasma concentrations by inducing CYP enzymes.
Phenobarbital
May decrease montelukast plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment recommended. Symptoms may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation
Drug Interactions
Rifampin
May decrease montelukast plasma concentrations by inducing CYP enzymes.
Phenobarbital
May decrease montelukast plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment recommended. Symptoms may include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in pediatric and adult patients for asthma and allergic rhinitis.
Lab Monitoring
- No routine laboratory monitoring required. Liver function tests may be considered in cases of suspected hepatic dysfunction.
Doctor Notes
- Emphasize adherence to daily dosing, even when asymptomatic.
- Counsel patients on potential psychiatric side effects and to report them promptly.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly.
- Report any new or worsening psychiatric symptoms immediately.
Missed Dose Advice
If a dose is missed, take the next dose at the regular scheduled time. Do not take a double dose to make up for a missed one.
Driving Precautions
Montelukast may cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Avoid known asthma triggers.
- Maintain a healthy lifestyle.
- Continue other asthma medications unless otherwise advised.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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